Molecular docking study of Keji Beling leave compound as protein 1J4X inhibitor to cervical cancer cell

VHR (Vaccinia H1-related phosphatase) is a protein that is involved in cervical cancer. 1J4X protein as a protein for cervical cancer cells is a structure of the VHR (Vaccinia H-1 related phosphate) receptor protein whose inhibition can reduce proliferation of cervical cancer cells. With current treatments which are expensive and cause side effects, alternative treatments are needed that are safe and do not cause side effects. Keji beling leaves are known to contain flavonoid compounds which are natural phenolic compounds that have the potential as anticancer. At present the design and development of new drugs can begin to be done in silico with biocomputing studies to analyze interactions known as molecular docking. With this method, the prediction of binding macromolecules (receptors) in the form of protein targets and small molecules (ligands) in the form of compound candidates can be carried out efficiently using software that utilizes docking algorithms and scoring functions. Molecular docking test results give the best docking score for quercetin which is -6.7, followed by n-hexadecanoic acid of -5.1 and finally 9-dodecenoic acid, methyl ester, (E) - worth -4.2 of 1J4X protein. Quercetin is a compound with the best inhibition potential against VHR which is indicated by the lowest docking score.