Molecular docking study of anti-inflammatory biomarkers in sulawesi propolis as potent inhibitors of cyclooxygenase-2

Darin Flamandita, Muhamad Sahlan, Kenny Lischer, Diah Kartika Pratami

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

NSAIDs seemingly arrived in their usage limitations as inflammatory drugs due to showing several side effects including gastrointestinal ulcerogenic activity and kidney dysfunction. Inflammatory response is known to be primarily controlled by Cyclooxygenase-2 (COX-2), thus suggesting it to be an important target for identifying novel inhibitor. Recently, Tetragonula biroi aff. stingless bee species from Sulawesi, Indonesia was known to have anti-inflammatory biomarkers, namely alpha-tocopherol succinate, xanthoxyletin, and deoxy-podophyllotoxin. Present study aims to discover new potent inhibitor of COX-2 from mentioned propolis by in silico approach. This experiment was used AutoDock Tools 1.5.6 to prepare the structure of ligand and protein, AutoDock Vina to evaluate the binding affinity and LigPlot to visualize in 2-dimensional graphic of the binding pose. Docking studies amongst three candidates revealed that xanthoxyletin found to be the most potent inhibitor of COX-2 with binding affinity of-8.9 kcal/mol.

Original languageEnglish
Title of host publication2nd IEEE International Conference on Innovative Research and Development, ICIRD 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728128252
DOIs
Publication statusPublished - Jun 2019
Event2nd IEEE International Conference on Innovative Research and Development, ICIRD 2019 - Depok, Indonesia
Duration: 28 Jun 201930 Jun 2019

Publication series

Name2nd IEEE International Conference on Innovative Research and Development, ICIRD 2019

Conference

Conference2nd IEEE International Conference on Innovative Research and Development, ICIRD 2019
CountryIndonesia
CityDepok
Period28/06/1930/06/19

Keywords

  • Anti-inflammatory
  • AutoDock Vina
  • COX-2 Inhibitor
  • Molecular Docking
  • Sulawesi Propolis

Fingerprint Dive into the research topics of 'Molecular docking study of anti-inflammatory biomarkers in sulawesi propolis as potent inhibitors of cyclooxygenase-2'. Together they form a unique fingerprint.

Cite this