Molecular docking bioactive compound from Strobilanthes crispus to decrease cholesterol levels

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Hypercholesterolemia is a disease caused by an increase in the concentration of cholesterol in the blood. One non-pharmacological treatment using herbal plants such as Strobilanthes crispus. This plant has flavonoid and phytosterols content that has been proven to reduce cholesterol levels in the blood. In this study, molecular docking was conducted to screen for the bioactive compounds that correspond to the interaction of the protein. Quercetin and β-sitosterol compounds are then docked using Autoodock Tools-1.5.6 to see the results of their affinity score for the HMG-CoA reductase enzyme. The affinity results obtained from quercetin, β-sitosterol and reference compounds (simvastatin) are -7.8 kcal/mol; -7.1 kcal/mol; and -6.1 kcal/mol. This shows that quercetin has the best affinity score for the inhibition of HMG-CoA reductase enzyme when compared with β-sitosterol and reference compounds.

Original languageEnglish
Title of host publication5th International Tropical Renewable Energy Conference, i-TREC 2020
EditorsRidho Irwansyah, Muhammad Arif Budiyanto
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735441286
DOIs
Publication statusPublished - 23 Sep 2021
Event5th International Tropical Renewable Energy Conference, i-TREC 2020 - Depok, Indonesia
Duration: 29 Oct 202030 Oct 2020

Publication series

NameAIP Conference Proceedings
Volume2376
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Tropical Renewable Energy Conference, i-TREC 2020
Country/TerritoryIndonesia
CityDepok
Period29/10/2030/10/20

Keywords

  • Bioactive Compound
  • Molecular Docking
  • Strobilanthes crispus

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