TY - JOUR
T1 - Modulation of immune responses by DNA damage signaling
AU - Uchihara, Yuki
AU - Permata, Tiara Bunga Mayang
AU - Sato, Hiro
AU - Shibata, Atsushi
N1 - Funding Information:
AS is supported by the Takeda Science Foundation , the SUNTORY Foundation for Life Sciences , The Sumitomo Foundation , Program of the Network Type Joint Usage/Research Center for Radiation Disaster Medical Science of Hiroshima University , Nagasaki University , and Fukushima Medical University , and the Japan Society for the Promotion of Science (grant number JP17H04713 ).
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/8
Y1 - 2021/8
N2 - An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses.
AB - An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses.
KW - Cancer therapy
KW - DNA damage signaling
KW - Immune crosstalk
KW - Immune-associated disease
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=85106368761&partnerID=8YFLogxK
U2 - 10.1016/j.dnarep.2021.103135
DO - 10.1016/j.dnarep.2021.103135
M3 - Article
C2 - 34029876
AN - SCOPUS:85106368761
SN - 1568-7864
VL - 104
JO - DNA Repair
JF - DNA Repair
M1 - 103135
ER -
