Modification of fast release fluoride varnish by addition of plant-based extracts as antibacterial agents

Karen Geraldine, Dhea Putriani, Yosi K. Eriwati, Heri Hermansyah

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Caries is an infection that destroys teeth structure and is caused by the activity of cariogenic bacteria, which are activated by the presence of carbohydrates. In 2018, it is recorded that 93% of children aged 5 to 6 experience caries disease. Topical therapy in the form of fluoride varnish is one of many ways to prevent caries on teeth. It is known that a variety of fluoride varnish with different flavor oil addition also have different fluoride release performance. This research will conduct a study of fluoride varnish formulation using addition of LorAnn Oils flavor oils with the flavors strawberry-kiwi, cinnamon roll, and marshmallow, and also natural antibacterial agents from extracts of pomegranate (Punica granatum) fruit, betle (Piper crocatum) leaves, and soursop (Annona muricata) leave obtained through maceration to inhibit Streptococcus mutans bacteria with the highest fluoride release rate. Fluoride release test is done in four hours by using fluoride ion selective electrode. Bacterial inhibition test is done by the disc diffusion method on Streptococcus mutans bacteria grown on BHI agar. The best fast release fluoride varnish is the one with an addition of 2% strawberry-kiwi flavor oil and 1 g/L addition of betle leaves extract, with a highest fluoride release at 72,29 mg/L at the fourth hour and an inhibition zone of 3,81 mm against Streptococcus mutans bacteria.

Original languageEnglish
Title of host publication5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 5th International Symposium of Biomedical Engineering, ISBE 2020
EditorsKenny Lischer, Sugeng Supriadi, Siti Fauziyah Rahman, Yudan Whulanza
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440869
DOIs
Publication statusPublished - 23 Mar 2021
Event5th International Symposium of Biomedical Engineering, ISBE 2020 - Depok, Virtual, Indonesia
Duration: 28 Jul 202029 Jul 2020

Publication series

NameAIP Conference Proceedings
Volume2344
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium of Biomedical Engineering, ISBE 2020
Country/TerritoryIndonesia
CityDepok, Virtual
Period28/07/2029/07/20

Keywords

  • antibacterial agent
  • caries
  • fast release fluoride varnish
  • fluoride ion release

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