TY - GEN
T1 - Modification of fast release fluoride varnish by addition of plant-based extracts as antibacterial agents
AU - Geraldine, Karen
AU - Putriani, Dhea
AU - Eriwati, Yosi K.
AU - Hermansyah, Heri
N1 - Funding Information:
Many thanks to the Department of Chemical Engineering, Faculty of Engineering and Faculty of Dentistry, Universitas Indonesia which all have been very generous in its support towards this research. We would also like to acknowledge the research support provided by Universitas Indonesia and Ministry of Research, Technology and Higher Education Republic of Indonesia through PUTI Prosiding Grant.
Publisher Copyright:
© 2021 Author(s).
PY - 2021/3/23
Y1 - 2021/3/23
N2 - Caries is an infection that destroys teeth structure and is caused by the activity of cariogenic bacteria, which are activated by the presence of carbohydrates. In 2018, it is recorded that 93% of children aged 5 to 6 experience caries disease. Topical therapy in the form of fluoride varnish is one of many ways to prevent caries on teeth. It is known that a variety of fluoride varnish with different flavor oil addition also have different fluoride release performance. This research will conduct a study of fluoride varnish formulation using addition of LorAnn Oils flavor oils with the flavors strawberry-kiwi, cinnamon roll, and marshmallow, and also natural antibacterial agents from extracts of pomegranate (Punica granatum) fruit, betle (Piper crocatum) leaves, and soursop (Annona muricata) leave obtained through maceration to inhibit Streptococcus mutans bacteria with the highest fluoride release rate. Fluoride release test is done in four hours by using fluoride ion selective electrode. Bacterial inhibition test is done by the disc diffusion method on Streptococcus mutans bacteria grown on BHI agar. The best fast release fluoride varnish is the one with an addition of 2% strawberry-kiwi flavor oil and 1 g/L addition of betle leaves extract, with a highest fluoride release at 72,29 mg/L at the fourth hour and an inhibition zone of 3,81 mm against Streptococcus mutans bacteria.
AB - Caries is an infection that destroys teeth structure and is caused by the activity of cariogenic bacteria, which are activated by the presence of carbohydrates. In 2018, it is recorded that 93% of children aged 5 to 6 experience caries disease. Topical therapy in the form of fluoride varnish is one of many ways to prevent caries on teeth. It is known that a variety of fluoride varnish with different flavor oil addition also have different fluoride release performance. This research will conduct a study of fluoride varnish formulation using addition of LorAnn Oils flavor oils with the flavors strawberry-kiwi, cinnamon roll, and marshmallow, and also natural antibacterial agents from extracts of pomegranate (Punica granatum) fruit, betle (Piper crocatum) leaves, and soursop (Annona muricata) leave obtained through maceration to inhibit Streptococcus mutans bacteria with the highest fluoride release rate. Fluoride release test is done in four hours by using fluoride ion selective electrode. Bacterial inhibition test is done by the disc diffusion method on Streptococcus mutans bacteria grown on BHI agar. The best fast release fluoride varnish is the one with an addition of 2% strawberry-kiwi flavor oil and 1 g/L addition of betle leaves extract, with a highest fluoride release at 72,29 mg/L at the fourth hour and an inhibition zone of 3,81 mm against Streptococcus mutans bacteria.
KW - antibacterial agent
KW - caries
KW - fast release fluoride varnish
KW - fluoride ion release
UR - http://www.scopus.com/inward/record.url?scp=85103513435&partnerID=8YFLogxK
U2 - 10.1063/5.0047551
DO - 10.1063/5.0047551
M3 - Conference contribution
AN - SCOPUS:85103513435
T3 - AIP Conference Proceedings
BT - 5th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Lischer, Kenny
A2 - Supriadi, Sugeng
A2 - Rahman, Siti Fauziyah
A2 - Whulanza, Yudan
PB - American Institute of Physics Inc.
T2 - 5th International Symposium of Biomedical Engineering, ISBE 2020
Y2 - 28 July 2020 through 29 July 2020
ER -