Modification of curcumin from turmeric rhizome (Curcuma longa) extract through O-ethylation with K2CO3/TBAB catalyst to enhance its antibacterial activity

S. H. Gustiani, E. Saepudin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Curcumin is a polyphenol compound contained in turmeric rhizome plants, and determines its pharmacological activity. Modification of curcumin structure has been explored to increase the lipophilicity of curcumin. The increase of lipophilicity is expected to enhance its bioactivity. This study aims to modify hydroxyl groups of curcumin by O-ethylation with diethyl carbonate that is environmentally friendly. Curcumin was modified into diethyl curcumin with a K2CO3 base catalyst under reflux conditions. TBAB (tetrabutylammonium bromide), as a Phase Transfer Catalyst (PTC), is added to this reaction system and has been shown to improve the synthesis results. The product has obtained percent yield of 89 % and characterized as diethyl curcumin. Curcumin and diethyl curcumin have shown an antibacterial activity against the growth of Gram-negative Escherichia coli bacteria, but did not inhibit the growth of Gram-positive Staphylococcus aureus bacteria.

Original languageEnglish
Title of host publicationProceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
EditorsTerry Mart, Djoko Triyono, Tribidasari Anggraningrum Ivandini
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735420014
DOIs
Publication statusPublished - 1 Jun 2020
Event5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 - Depok, Indonesia
Duration: 9 Jul 201910 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2242
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
CountryIndonesia
CityDepok
Period9/07/1910/07/19

Keywords

  • antibacterial
  • Curcumin
  • diethyl carbonate
  • KCO/TBAB
  • o-ethylation reaction

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    Gustiani, S. H., & Saepudin, E. (2020). Modification of curcumin from turmeric rhizome (Curcuma longa) extract through O-ethylation with K2CO3/TBAB catalyst to enhance its antibacterial activity. In T. Mart, D. Triyono, & T. A. Ivandini (Eds.), Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 [040006] (AIP Conference Proceedings; Vol. 2242). American Institute of Physics Inc.. https://doi.org/10.1063/5.0007920