Minimal Physiologically-based Pharmacokinetic Model to Investigate the Effect of Charge on the Pharmacokinetics of Humanized anti-HCV-E2 IgG Antibodies in Sprague–Dawley Rats

Keyphrases

• Anti-HCV 100%
• Humanized 100%
• Pharmacokinetics 100%
• IgG Antibody 100%
• Physiologically-based Pharmacokinetic Model 100%
• Interstitial Space 80%
• FcRn Binding 60%
• Binding Affinity 40%
• Metabolism 40%
• Point Values 40%
• Drug Exposure 40%
• Cellular Uptake 40%
• FcRn 40%
• Sweet 20%
• Solid Tumors 20%
• Isoelectric Point 20%
• External Validation 20%
• Close Contact 20%
• Quantitative Relationship 20%
• Space Distribution 20%
• Design Futures 20%
• Pharmacokinetic Data 20%
• Parameter Relations 20%
• Space Exposure 20%
• Pharmacokinetic Properties 20%
• High Interstitial 20%
• Charging Parameters 20%
• Monoclonal IgG Antibodies 20%
• Model-based Simulation 20%

Immunology and Microbiology

• Immunoglobulin G 100%
• Pharmacokinetics 100%
• Blood Plasma 27%
• Binding Affinity 18%
• Drug Exposure 18%
• Isoelectric Point 9%
• Immunoglobulin G Antibody 9%

Pharmacology, Toxicology and Pharmaceutical Science

• Immunoglobulin G 100%
• Pharmacokinetics 100%
• Solid Malignant Neoplasm 9%
• Immunoglobulin G Antibody 9%
• Isoelectric Point 9%