TY - JOUR
T1 - MIKROENKAPSULASI PROPANOLOL HIDROKLORIDA DENGAN PENYALUT ETIL SELULOSA MENGGUNAKAN METODA PENGUAPAN PELARUT
AU - Sutriyo, null
AU - Djajadisastra, Joshita
AU - Novitasari, Adilla
PY - 2004
Y1 - 2004
N2 - Propranolol hydrochloride is antihypertension agent that has a short biological half life of 2-6 hours. Microcapsules of propranolol hydrochloride are prepared by solvent evaporation method using ethylcellulose as a wall material with the drug-polymer ratio 1:1, 1:2, and 1:3 for sustained release oral delivery. The microcapsules were then evaluated by particle size distribution analysis, shape and morphology (SEM), drug content, and dissolution studies. In vitro dissolution was studied using the dissolution apparatus II (paddle) with chloride buffer (pH 1,2) dan phosphate buffer (pH 6,8) medium. The drug-polymer ratio have an important influence on drug release from microcapsules where the increase of polymer cause the higher drug release inhibition.
AB - Propranolol hydrochloride is antihypertension agent that has a short biological half life of 2-6 hours. Microcapsules of propranolol hydrochloride are prepared by solvent evaporation method using ethylcellulose as a wall material with the drug-polymer ratio 1:1, 1:2, and 1:3 for sustained release oral delivery. The microcapsules were then evaluated by particle size distribution analysis, shape and morphology (SEM), drug content, and dissolution studies. In vitro dissolution was studied using the dissolution apparatus II (paddle) with chloride buffer (pH 1,2) dan phosphate buffer (pH 6,8) medium. The drug-polymer ratio have an important influence on drug release from microcapsules where the increase of polymer cause the higher drug release inhibition.
UR - http://psr.ui.ac.id/index.php/journal/article/view/3373
U2 - 10.7454/psr.v1i2.3373
DO - 10.7454/psr.v1i2.3373
M3 - Article
SN - 1693-9883
VL - 1
SP - 93
EP - 101
JO - Majalah Ilmu Kefarmasian
JF - Majalah Ilmu Kefarmasian
IS - 2
ER -