Microwave assisted synthesis of pyridin-1-ium salt of 6-nitroquinazolin-4-one and its 6-amino analog under ultrasonic irradiation

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Abstract

The new compounds of quinazolin-4-one derivative i.e., 2-methyl-6-nitroquinazolin-4-one substituted pyridin-1-ium salt at methyl group and its 6-amino analog have been synthesized. Microwave irradiation of solution of 2-bromomethyl-6- nitroquinazolin-4-one and pyridine in acetonitrile for 3 min afforded 1-[(6-nitroquinazolin-4-one-2-yl)methyl]pyridin-1-ium bromide; and nitro reduction of the product with iron in ethanol/acetic acid/water under ultrasonic irradiation afforded 1-[(6-aminoquinazolin-4-one-2-yl)methyl]pyridin-1-ium bromide. The structure of the synthesized compounds were confirmed on the basis of FT-IR, 1H NMR and 13C NMR data.

Original languageEnglish
Pages (from-to)7904-7906
Number of pages3
JournalAsian Journal of Chemistry
Volume26
Issue number23
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • 6-Aminoquinazolin-4-one
  • 6-Nitroquinazolin-4-one
  • Aqueous media
  • Microwave
  • Pyridinium salt
  • Quinazolin-4-one
  • Ultrasound

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