Abstract
The new compounds of quinazolin-4-one derivative i.e., 2-methyl-6-nitroquinazolin-4-one substituted pyridin-1-ium salt at methyl group and its 6-amino analog have been synthesized. Microwave irradiation of solution of 2-bromomethyl-6- nitroquinazolin-4-one and pyridine in acetonitrile for 3 min afforded 1-[(6-nitroquinazolin-4-one-2-yl)methyl]pyridin-1-ium bromide; and nitro reduction of the product with iron in ethanol/acetic acid/water under ultrasonic irradiation afforded 1-[(6-aminoquinazolin-4-one-2-yl)methyl]pyridin-1-ium bromide. The structure of the synthesized compounds were confirmed on the basis of FT-IR, 1H NMR and 13C NMR data.
Original language | English |
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Pages (from-to) | 7904-7906 |
Number of pages | 3 |
Journal | Asian Journal of Chemistry |
Volume | 26 |
Issue number | 23 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- 6-Aminoquinazolin-4-one
- 6-Nitroquinazolin-4-one
- Aqueous media
- Microwave
- Pyridinium salt
- Quinazolin-4-one
- Ultrasound