Microwave-assisted one-pot multicomponent synthesis of 1,4-dihydropyridine derivatives using nanochitosan

D. Febriantini, A. H. Cahyana, R. T. Yunarti, A. R. Liandi, B. Ardiansah

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

A facile heterogeneous synthesis of 1,4-dihydropyridine was effectively conducted using one-pot three component-coupling of an aromatic aldehyde, an active methylene substance, and ammonium acetate in the presence of nanochitosan as a biopolymer catalytic system under solvent-free microwave-irradiation conditions in satisfactory yields. Chitosan nanocatalyst with a minimum particle size of < 100 nm was synthesized by crosslinking low molecular weight chitosan with polyanion sodium tripolyphosphate and physicochemically analyzed. The products of Hantzsch reaction obtained were determined by FTIR, UV/Vis spectrophotometer, and mass analysis. The antioxidant properties of the compounds were analyzed using DPPH method. The present method offers several advantages including easy isolation of products, easier work-up procedure, green conditions, excellent yields and short reaction time.

Original languageEnglish
Title of host publicationProceedings of the 4th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2018
EditorsTerry Mart, Djoko Triyono, Ivandini T. Anggraningrum
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419155
DOIs
Publication statusPublished - 4 Nov 2019
Event4th International Symposium on Current Progress in Mathematics and Sciences 2018, ISCPMS 2018 - Depok, Indonesia
Duration: 30 Oct 201831 Oct 2018

Publication series

NameAIP Conference Proceedings
Volume2168
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium on Current Progress in Mathematics and Sciences 2018, ISCPMS 2018
CountryIndonesia
CityDepok
Period30/10/1831/10/18

Keywords

  • antioxidant
  • biopolymer
  • DPPH method
  • Hantzsch reaction
  • Nanochitosan

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