Methylation Profile of HOXA 11 Gene in Eutopic Endometrium on Endometriosis Patient with Infertility

Muharam Natadisastra, Valencia Yuwono, Ririn Febri, Asmarinah

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To investigate the HOXA11 gene profile on endometriosis
patients with infertility in Indonesia.
Methods: This cross sectional study was conducted in Dr. Cipto
Mangunkusumo Hospital from July 2015- June 2016. The subjects
were endometriosis patients with infertility who have been
confirmed histopathological. The control group was taken from
non-endometriosis and fertile patients. Eutopic endometrium
samples were taken and examined for the methylation of HOXA 11
gene.
Results: Both groups consist of six patients. The difference of
methylation of HOXA 11 gene between those two groups is
statistically significant (p=0.03). There was hyper methylation in
endometriosis group.
Conclusion: There is a hyper methylation of HOXA 11 gene in
eutopic endometrium of endometriosis patients with infertility.
Thus, possibly can explain the poor endometrial receptivity
in endometriosis patient and give a broad research area in
epigenetic therapy of endometriosis.
Original languageEnglish
Pages (from-to)110-113
JournalIndonesian Journal of Obstetrics and Gynecology
DOIs
Publication statusPublished - 2 Apr 2018

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