Methyl ferulate from methanol extract of Indonesian sausage fruit (Kigelia africana)

A. Ilmiawati, D. Anggraini, G. Syahbirin, D. U.C. Rahayu, P. Sugita

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Sausage tree (Kigelia africana) is a medicinal plant of Bignoniaceae family which can be used as anticancer. Study on K. africana as an anticancer activity is still restricted to its crude extract while the structure of its active compound is still limited. On the other hand, K. africana in Indonesia has not been used as a medicine. It is only used as an ornamental plant because of its unique fruit shape. Therefore, it is interesting to conduct a research on isolation of active compounds from K. africana having anticancer activity. Simplicia of K. africana fruit was macerated in methanol and fractionated using vacuum liquid chromatography obtained 6 fractions (A-F). Fraction C was further fractionated using radial chromatography yielded 5 sub-fractions. Sub-fractions C3 and C4 were purified by preparative thin layer chromatography and obtained cinnamate derivative. Based on NMR and LC-MS spectral data, cinnamate derivative was identified as methyl ferulate. This study reported the isolation of methyl ferulate from K. africana which can be examined to its anticancer activity in further research.

Original languageEnglish
Title of host publication8th International Conference of the Indonesian Chemical Society, ICICS 2019
EditorsMohamad Rafi, Rudi Heryanto, Wulan Tri Wahyuni
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735420021
DOIs
Publication statusPublished - 4 Jun 2020
Event8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019 - Bogor, Indonesia
Duration: 6 Aug 20197 Aug 2019

Publication series

NameAIP Conference Proceedings
Volume2243
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019
CountryIndonesia
CityBogor
Period6/08/197/08/19

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