Professional Nursing Practice model has been being utilized either in developed countries or in developing countries. In Indonesia, specifically in Jakarta it has been being employed for almost 3 years. The purpose of this article is todesiminate information on Professional Nursing Practice in Irna B, IV floor RSUPN Cipto Mangunkusumo. This professional practice model is based on a cooperation between FIK-UI and RSUPN Cipto Mangunkusumo to improne the delivery of nursing service the focus is on comprehensive ness of the nursing care which is supported by group dynamic and integrated collaboration. There are 3 main aspects of working mechanism in this model namely: adequate nursing personnel, method of nursing assignment, and documentation system.