Median Lethal Dose (Ld50) Test of Analgesic Herbal Jatropha Curcas L. Latex on Animal Models

Irmaleny, Narlan Sumawinata, Dewi Fatma, Marline Abdassah

Research output: Contribution to journalArticlepeer-review


Dental pain is a common illness suffered by society. One of the plants that are commonly used for dental pain relief is the latex of Jatropha curcas L. Scientific data regarding the analgesic effect of Jatropha curcas L. latex has been widely studied, but there is no scientific data about the safety of its use. This study aimed to evaluate of the safety usage of Jatropha curcas L., by performing an acute toxicity test to obtain a median lethal dose (LD50). Mus musculus Swiss-Webster strain was divided into 6 groups (control group was given PGA 10%, and the first to the fifth group were given latex orally at doses of 30, 40, 50, 60, 70 g/kg body weight respectively). The mortality of the animal was measured every day for 14 days. The data were depicted with log-probit graphic method for determined value LD50. LD50 was 50 g/kg body weight. Conclusion: The latex of Jatropha curcas L. was classified as non-toxic material.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalJournal of International Dental and Medical Research
Issue number1
Publication statusPublished - 2022


  • Acute toxicity test
  • Jatropha curcas l. latex
  • Median lethal dose


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