Mechanical evaluation of effect of grape seed proanthocyanidins extract on debilitated mandibles in rats

Masaru Gunjima, Iwan Tofani, Yukimi Kojima, Kenshi Maki, Mitsutaka Kimura

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Grape seed proanthocyanidins extract (GSPE), whose principal ingredient is proanthocyanidins, shows many activities such as cholesterol lowering effects, antioxidant effects, anti-tumor effects, cardioprotective effects, and protection against ultraviolet rays. However, reports of the effects of GSPE on bone are rare. We performed a mechanical analysis of the effect of GSPE on the interior structure of rat mandibular bone in the growth period, using three-dimensional peripheral quantitative computed tomography (pQCT). A low-calcium /high-calcium diet with supplementary GSPE was compared to a low-calcium/high-calcium diet in rats with debilitated mandibular bones. The group who received added GSPE showed a significant increase in cortical bone density, cross-sectional area, and trabecular bone mineral content (p<0.05). A significant increase was also seen in the results of a non-invasive stress strain index (SSI) (p<0.01) in the added GSPE. Our findings suggest that GSPE can increase bone quality and bone strength of rat mandibles in the growth period.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalDental Materials Journal
Volume23
Issue number2
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • GSPE
  • Rat mandible
  • pQCT

Fingerprint Dive into the research topics of 'Mechanical evaluation of effect of grape seed proanthocyanidins extract on debilitated mandibles in rats'. Together they form a unique fingerprint.

Cite this