Maximizing periodontal defect creation and experimental design in non-human primate model study: An updated review article

Benso Sulijaya, Herlis Rahdewati, Hari Sunarto, Yuniarti Soeroso

Research output: Contribution to journalArticlepeer-review

Abstract

In relation to periodontal defect, several animals such as rats, hamster, rabbit, dog and non-human primate were used to prove the finding in in vitro study and to confirm the efficacy of new material or therapy before settled in human. This review aimed to describe and investigate the use of non-human primate as an animal model in periodontal defect to maximize the experiment design. Potentially relevant electronic or on-line article from Google Scholar, Science Direct, and PUBMED was screened. Full-text or articles written in English up to November 2017 were collected. Keywords or phrases were used: (Non-human primate OR monkey OR macaca) AND (periodontal defect). Non-human primate animal was reported prone to have systemic infectious disease such as tuberculosis. However, the use of non-human primate in experiment is ethically restricted; it should be performed on the highest beneficial reason. Combination of acute-chronic defect model in non-human primate is the best way to imitate a periodontitis condition in human. A notch in the base is made as a mark to measure the gain of periodontal ligament, new bone and cementum formations. Due to its limited number of animals used in a study, a good and reliable experimental design is needed.

Original languageEnglish
Pages (from-to)733-737
Number of pages5
JournalJournal of International Dental and Medical Research
Volume12
Issue number2
Publication statusPublished - 1 Jan 2019

Keywords

  • Animal study
  • Non-human primate
  • Periodontal defect
  • Periodontitis
  • Review

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