Maternal and cord blood cyclophilin A in severe preeclampsia and normal pregnancy and its correlation with vitamin D and zinc

Noroyono Wibowo, Riyan Hari Kurniawan, Rima Irwinda, Natasya Prameswari

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Objective: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level. Methods: We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014. Results: Thirty-nine subjects were included. Subjects with severe preeclampsia have higher serum cyclophilin A levels compared with normotensive pregnancy (1299.60 vs. 1039.50; p 0.017). Maternal cyclophilin A, vitamin D, and zinc correlation were not statistically significant (p 0.189 & p 0.853). Conclusion: Cyclophilin A levels in severe preeclampsia is higher compared to normal pregnancy. There is no correlation between cyclophilin A, zinc, and vitamin D.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalHypertension in Pregnancy
Volume36
Issue number4
DOIs
Publication statusPublished - 2 Oct 2017

Keywords

  • Cyclophilin A
  • CyPA
  • severe preeclampsia
  • vitamin D
  • zinc

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