Manzamine Alkaloids from an Acanthostrongylophora sp. Sponge

Chang Kwon Kim, Riswanto Riswanto, Tae Hyung Won, Heegyu Kim, Berna Elya, Chung J. Sim, Dong Chan Oh, Ki Bong Oh, Jongheon Shin

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Five new manzamine alkaloids (1-5) and new salt forms of two known manzamines (6 and 7), along with seven known compounds (8-14) of the same structural class, were isolated from an Indonesian Acanthostrongylophora sp. sponge. On the basis of the results of combined spectroscopic analyses, the structure of kepulauamine A (1) was determined to possess an unprecedented pyrrolizine moiety, while others were functional group variants of known manzamines. These compounds exhibited weak cytotoxicity, moderate antibacterial activity, and mild inhibition against the enzyme isocitrate lyase.

Original languageEnglish
Pages (from-to)1575-1583
Number of pages9
JournalJournal of Natural Products
Issue number5
Publication statusPublished - 26 May 2017


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