TY - JOUR
T1 - Malnutrition-inflammation syndrome in a hemodialysis population
T2 - the influence of polymorphic IL-6-174 and IL-10-1082 genes.
AU - Suhardjono, null
PY - 2006
Y1 - 2006
N2 - AIM: To find out inflammation prevalence in hemodialysis patients and whether polymorphic gene IL-6-174 and IL-10-1082 had prominent factors in malnutrition inflammation syndrome. METHODS: A study on 81 patients who were on hemodialysis twice a week, 5 hours each session has been conducted. The subjects had no other co-morbidities and all of them used reprocessed diacetate cellulose dialyzers. RESULTS: It was obtained that CRP blood level (6.23+/- 5.57 mg/L), inflammation prevalence (23.5%), and malnutrition inflammation score (6.7) were lower compared with the data from Europe and the United States. Out of 64 patients examined, IL-6-174GG 95.31%, CC 3.13% and GC 1.56%, IL-1082AA 89.06%, GA 10.94%, but absence of GG genotype. Considering the scanty amount of allele C in IL-6-174 gene and G allele in IL-10-1082 gene, based on the statistic analysis performed, it did not reveal the influence of the difference in allele on the clinical manifestation. The proportion of these alleles were almost similar to that obtained in Korea, Japan and China, but it was different from that obtained in the US and in Europe. A very resolute impression was obtained in HD patients in Jakarta that IL-6-174GG gene was protective in nature whereas IL-10-1082 AA gene had a less considerable role. CONCLUSION: The prevalence of inflammation and malnutrition-inflammation parameters (CRP, malnutrition Inflammation Score) in our HD patients were lower than that reported in Western countries. This might be related to the low prevalence of IL-6-174C allele in our population.
AB - AIM: To find out inflammation prevalence in hemodialysis patients and whether polymorphic gene IL-6-174 and IL-10-1082 had prominent factors in malnutrition inflammation syndrome. METHODS: A study on 81 patients who were on hemodialysis twice a week, 5 hours each session has been conducted. The subjects had no other co-morbidities and all of them used reprocessed diacetate cellulose dialyzers. RESULTS: It was obtained that CRP blood level (6.23+/- 5.57 mg/L), inflammation prevalence (23.5%), and malnutrition inflammation score (6.7) were lower compared with the data from Europe and the United States. Out of 64 patients examined, IL-6-174GG 95.31%, CC 3.13% and GC 1.56%, IL-1082AA 89.06%, GA 10.94%, but absence of GG genotype. Considering the scanty amount of allele C in IL-6-174 gene and G allele in IL-10-1082 gene, based on the statistic analysis performed, it did not reveal the influence of the difference in allele on the clinical manifestation. The proportion of these alleles were almost similar to that obtained in Korea, Japan and China, but it was different from that obtained in the US and in Europe. A very resolute impression was obtained in HD patients in Jakarta that IL-6-174GG gene was protective in nature whereas IL-10-1082 AA gene had a less considerable role. CONCLUSION: The prevalence of inflammation and malnutrition-inflammation parameters (CRP, malnutrition Inflammation Score) in our HD patients were lower than that reported in Western countries. This might be related to the low prevalence of IL-6-174C allele in our population.
UR - http://www.scopus.com/inward/record.url?scp=39049187491&partnerID=8YFLogxK
M3 - Article
C2 - 17132891
AN - SCOPUS:39049187491
VL - 38
SP - 145
EP - 149
JO - Acta medica Indonesiana
JF - Acta medica Indonesiana
SN - 2338-2732
IS - 3
ER -