TY - JOUR
T1 - Lymphatic filariasis and Brugia timori
T2 - Prospects for elimination
AU - Fischer, Peter
AU - Supali, Taniawati
AU - Maizels, Rick M.
N1 - Funding Information:
We thank Paul Rückert, Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ), Kupang, Indonesia, Paul Manoempil, District Health Administration, Kalabahi, Alor and their teams for their encouragement during the field work. We thank Eric A. Ottesen, Rollins School for Public Health, Atlanta, and Dietrich W. Büttner, Bernhard Nocht Institute, Hamburg, for critically reading the manuscript. The studies were supported by grants of WHO/TDR, GlaxoSmithKline and GTZ. The studies would have been not possible without the help and understanding of the study population in Mainang village.
PY - 2004/8/1
Y1 - 2004/8/1
N2 - Brugia timori is a pathogenic filarial nematode of humans, replacing the closely related species Brugia malayi on some islands in eastern Indonesia. Recent studies on Alor island show that, locally, B. timori is still of great public health importance, causing mainly acute filarial fever and chronic lymphedema. PCR-based assays to detect parasite DNA, in addition to assays for detecting specific antibodies that have been originally developed for B. malayi, can be used efficiently as diagnostic tools for B. timori. In the framework of the Global Program to Eliminate Lymphatic Filariasis, a single annual dose of diethylcarbamazine, in combination with albendazole, was found to reduce the prevalence and density of microfilaraemia persistently. Therefore, elimination of B. timori appears to be achievable.
AB - Brugia timori is a pathogenic filarial nematode of humans, replacing the closely related species Brugia malayi on some islands in eastern Indonesia. Recent studies on Alor island show that, locally, B. timori is still of great public health importance, causing mainly acute filarial fever and chronic lymphedema. PCR-based assays to detect parasite DNA, in addition to assays for detecting specific antibodies that have been originally developed for B. malayi, can be used efficiently as diagnostic tools for B. timori. In the framework of the Global Program to Eliminate Lymphatic Filariasis, a single annual dose of diethylcarbamazine, in combination with albendazole, was found to reduce the prevalence and density of microfilaraemia persistently. Therefore, elimination of B. timori appears to be achievable.
UR - http://www.scopus.com/inward/record.url?scp=3142737318&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2004.06.001
DO - 10.1016/j.pt.2004.06.001
M3 - Short survey
C2 - 15246315
AN - SCOPUS:3142737318
SN - 1471-4922
VL - 20
SP - 351
EP - 355
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 8
ER -
