Low vitamin D-25(OH) level in Indonesian multiple sclerosis and neuromyelitis optic patients

Winda Kusumadewi, Darma Imran, Fiastuti Witjaksono, Trevino Aristarkus Pakasi, Ahmad Irwan Rusmana, David Pangeran, Sarah Shafa Marwadhani, Kartika Maharani, Riwanti Estiasari

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background: Vitamin D deficiency is commonly found in multiple sclerosis (MS) and Neuromyelitis Optic (NMO) patients and can impair the immunological status. As a tropical country, Indonesia has a lot of sunshine throughout the year as a source of vitamin D. The aim of this study was to evaluate and compare the serum vitamin D-25(OH) level in Indonesian MS and NMO patients to healthy individuals. Methods: A cross-sectional study was conducted in Dr. Cipto Mangunkusumo General Hospital Jakarta from November 2016 to May 2017. Forty-eight patients (29 MS and 19 NMO) and 33 healthy controls were enrolled. We assessed the dietary recall, vitamin D supplementation, sunshine exposure, medication, annual relapse rate, and Expanded Disability Status Scale (EDSS). Vitamin D level was measured using direct competitive chemiluminescence immunoassay. Results: Vitamin D deficiency was found in 48.4% of MS and 56.2% of NMO patients. The serum vitamin D level in MS and NMO groups was not significantly different from the healthy controls. Vitamin D level was not associated with EDSS and the annual relapse rate. Positive significant correlation was observed between sunshine exposure and vitamin D level in healthy control, but not evident in MS and NMO groups. MS and NMO subjects who still treated with corticosteroid had lower vitamin D level. Conclusion: Vitamin D deficiency is commonly found in Indonesian MS and NMO patients, but not associated with EDSS and annual relapse rate. Despite living in a country with adequate sunshine exposure, the physician should anticipate low serum vitamin D level, especially in MS or NMO patients who received corticosteroid.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalMultiple Sclerosis and Related Disorders
Volume25
DOIs
Publication statusPublished - 1 Oct 2018

Keywords

  • Demyelinating diseases
  • Expanded Disability Status Scale (EDSS)
  • Indonesia
  • Multiple sclerosis (MS)
  • Neuromyelitis optic (NMO)
  • Vitamin D

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