TY - JOUR
T1 - Low Alveolar Macrophages Function, Low Balf IL-6 Level and High Balf CD4 Cell Count Is Associated with Successful Extubation and Survival in Severe Pneumonia Patients
AU - Rengganis, Iris
AU - R., Cleopas Martin
AU - Harimurti, Kuntjoro
AU - Singh, Gurmeet
PY - 2024
Y1 - 2024
N2 - Background: To assess Bronchoalveolar-Lavage Fluid (BALF) biomarker inter-relationship of severely affected lung and their association in determining successful extubation and survival. Methods: This prospective cohort study enrolled one hundred thirty-seven hospitalized severe pneumonia patients admitted to the Resuscitation Emergency Unit/Intensive Care Unit (REU/ICU) of Cipto Mangunkusumo Hospital, Indonesia from November 2020 – January 2021. Inclusion criteria: aged 18 years or older; severe pneumonia (IDSA/ATS 2007 criteria); can undergo bronchoscopy within 12 hours of admission to REU/ICU; receive empirical antibiotics of no more than 24 hours; and intubated within 24 hours. Exclusion criteria: acute respiratory distress syndrome (ARDS) non-infection; HIV/AIDS (confirmed by rapid anti-HIV testing); active malignancy within the last 12 months; on immunosuppressant therapy; refused to undergo bronchoscopy. Univariate analysis was performed for subject characteristics and bivariate analysis was performed for BALF biomarkers (sTREM, alveolar macrophages, IL-6, IL-17, CD4, Treg Foxp3+, SP-A and caspase-3). All p values <.05 were considered statistically significant.
AB - Background: To assess Bronchoalveolar-Lavage Fluid (BALF) biomarker inter-relationship of severely affected lung and their association in determining successful extubation and survival. Methods: This prospective cohort study enrolled one hundred thirty-seven hospitalized severe pneumonia patients admitted to the Resuscitation Emergency Unit/Intensive Care Unit (REU/ICU) of Cipto Mangunkusumo Hospital, Indonesia from November 2020 – January 2021. Inclusion criteria: aged 18 years or older; severe pneumonia (IDSA/ATS 2007 criteria); can undergo bronchoscopy within 12 hours of admission to REU/ICU; receive empirical antibiotics of no more than 24 hours; and intubated within 24 hours. Exclusion criteria: acute respiratory distress syndrome (ARDS) non-infection; HIV/AIDS (confirmed by rapid anti-HIV testing); active malignancy within the last 12 months; on immunosuppressant therapy; refused to undergo bronchoscopy. Univariate analysis was performed for subject characteristics and bivariate analysis was performed for BALF biomarkers (sTREM, alveolar macrophages, IL-6, IL-17, CD4, Treg Foxp3+, SP-A and caspase-3). All p values <.05 were considered statistically significant.
KW - Successful extubation
KW - alveolar macrophages
KW - IL-6
KW - CD4
KW - severe pneumonia
UR - https://www.indonesiajournalchest.com/index.php/IJC/issue/view/249
M3 - Article
SN - 2614-2759
VL - 11
JO - Indonesian Journal Chest & Critical Care Medicine
JF - Indonesian Journal Chest & Critical Care Medicine
IS - 1
ER -