@article{f07810c0d20d4b9387c88559b023b0e2,
title = "Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes",
abstract = "We evaluated the impact of 6-month probiotics and calcium supplementation at 1–6 years of age on neurodevelopment in adolescence, along with the effects of other biomedical and socioenvironmental factors. We re-enrolled 238 adolescents 10-years after supplementation with low-lactose milk with either low calcium (LC; ∼50 mg/d; n = 53), regular calcium (RC; ∼440 mg/d; n = 70), RC with 5x108 CFU/d Lactobacillus reuteri DSM17938 (reuteri; n = 55), or RC with 5x108 CFU/d L. casei CRL431 (casei; n = 60). Compared to RC, the casei group scored 0.38 SD (effect size, 0.04–0.72) higher on the Raven's Progressive Matrices; the reuteri group was 0.38 SD (0.01–0.75) lower on the Children's Depression Inventory; and the LC and younger adolescents in the reuteri group were 0.36 (0.01–0.71) and 0.49 SD (0.02–0.95) lower in brain-derived neurotrophic factor. Diet quality, physical activity, and home environment contributed similar effect sizes. Probiotics supplementation in childhood have strain-specific long-term neurodevelopmental benefits and integration with socioenvironmental interventions are warranted.",
keywords = "BDNF, Calcium, Casei, Cognition, Probiotic, Reuteri",
author = "Davrina Rianda and Suradijono, {Sri Hartati R.} and Setiawan, {Evania A.} and Fenny Susanto and Meilianawati Meilianawati and Erfi Prafiantini and Kok, {Frans J.} and Shankar, {Anuraj H.} and Rina Agustina",
note = "Funding Information: This work was supported by the Ministry of Research, Technology, and Higher Education of the Republic of Indonesia [grant numbers NKB- 1886/UN2.R3.1/HKP.05.00/2019 ]; and by the Directorate of Research and Community Engagement, Universitas Indonesia, Q1Q2 Publication [grant numbers NKB-0233/UN2.R3.1/HKP.05.00/2019S ]. We thank the participants and their parents for their involvement in our follow-up study, also cadres who helped us in tracking the subjects from the original study. The primary RCT was organized by R.A. as the Principal Investigator with a grant from Tops Institute of Food and Nutrition, Wageningen, Netherlands provided to the Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON), Jakarta, Indonesia; with support from Wageningen University, NIZO food research, Netherlands; Unilever Research and Development, Vlaardingen, Netherlands; FrieslandCampina Research, Deventer, Netherlands. We thank the team from the original study (Ruud Albers, Ellen G.H.M van den Heuvel, Ingeborg M. J. Bovee-Oudenhoven, Agus Firmansyah (late), Widjaja Lukito) for their support on the follow-up study. Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = apr,
doi = "10.1016/j.jff.2022.105014",
language = "English",
volume = "91",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Ltd",
}