@article{79d4d098e6aa44d78fc5c9eb2a0271aa,
title = "Ligand exchange strategy for delivery of ruthenium complex unit to biomolecules based on ruthenium-olefin specific interactions",
abstract = "Ligand exchange reactions between a Hoveyda-Grubbs-type complex and 2-alkoxybenzylidene in a biomolecule assist in the delivery of a ruthenium complex unit to the biomolecule. Complexes having an electron-withdrawing group in their ligands efficiently transfer a ruthenium complex unit onto peptides. This method is also applicable for adenylate kinase, an experimental model protein. The ligand exchange reaction originates from ruthenium-olefin specific interactions and potentially provides a bioorthogonal method for chemical modification of biomacromolecules with transition metal complexes.",
keywords = "Ligand exchange, Protein modification, Ru-olefin interaction",
author = "Catur Jatmika and Kazumo Wakabayashi and Ryosei Tamaki and Naoki Akiyama and Ibuki Nakamura and Shun Hirota and Hiroyasu Yamaguchi and Takashi Matsuo",
note = "Funding Information: This work was supported by a Grant-in Aid for Scientific Research on Innovative Areas “Molecular Engine” (JSPS KAKENHI Grant Number JP19H05395 (to T.M.)) and by a Grant-in Aid for Scientific Research on Innovative Areas “Precisely Designed Catalysts with Customized Scaffolding” (JSPS KAKENHI Grant Number JP15H05807 (to H.Y.); JP 16H01029 (to T.M.)). The authors acknowledge Yoshiko Nishikawa for support of mass analyses. Publisher Copyright: {\textcopyright} 2020 Chemical Society of Japan. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
doi = "10.1246/CL.200590",
language = "English",
volume = "49",
pages = "1490--1493",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "The Chemical Society of Japan",
number = "12",
}