TY - GEN
T1 - Levels of interleukin-1β in gingival crevicular fluid in patients with coronary heart disease and its relationship to periodontal status
AU - Lenggogeny, Putri
AU - Masulili, Sri Lelyati C.
AU - Tadjoedin, Fatimah M.
AU - Radi, Basuni
N1 - Publisher Copyright:
© 2017 Author(s).
PY - 2017/2/21
Y1 - 2017/2/21
N2 - Periodontitis is a risk factor for coronary heart disease (CHD). Both diseases are an inflammatory diseases and have the same potential pathogenic mechanisms. Interleukin-1β as a pro-inflammatory main cytokine, can be found in this both diseases. Gingival crevicular fluid (GCF) derived from the serum of gingival sulcus, affected by inflammatory mechanism and the amount of this fluid will increase in that situation. Objective: To analyze the relationship of interleukin-1β levels in gingival crevicular fluid (GCF) of CHD and non-CHD patients with periodontal status. Methods: Oral clinical examination (plaque index, bleeding on probing, pocket depth and clinical attachment loss) for 35 subjects with CHD and 35 non CHD were checked, laboratory test to measure the levels of Interleukin-1β was checked with enzyme-linked immunosorbent assay (ELISA). Results: There was no significant differences between interleukin-1β levels in CHD and non-CHD patients (p>0.05); there was no significant difference between the level of Interleukin-1β with periodontal status in CHD and control (non CHD) patients (p>0.05). Conclusions: levels of Interleukin-1β in CHD patients do not have a relationships with plaque index, pocket depth and clinical attachment loss, but has a relationships with bleeding on probing.
AB - Periodontitis is a risk factor for coronary heart disease (CHD). Both diseases are an inflammatory diseases and have the same potential pathogenic mechanisms. Interleukin-1β as a pro-inflammatory main cytokine, can be found in this both diseases. Gingival crevicular fluid (GCF) derived from the serum of gingival sulcus, affected by inflammatory mechanism and the amount of this fluid will increase in that situation. Objective: To analyze the relationship of interleukin-1β levels in gingival crevicular fluid (GCF) of CHD and non-CHD patients with periodontal status. Methods: Oral clinical examination (plaque index, bleeding on probing, pocket depth and clinical attachment loss) for 35 subjects with CHD and 35 non CHD were checked, laboratory test to measure the levels of Interleukin-1β was checked with enzyme-linked immunosorbent assay (ELISA). Results: There was no significant differences between interleukin-1β levels in CHD and non-CHD patients (p>0.05); there was no significant difference between the level of Interleukin-1β with periodontal status in CHD and control (non CHD) patients (p>0.05). Conclusions: levels of Interleukin-1β in CHD patients do not have a relationships with plaque index, pocket depth and clinical attachment loss, but has a relationships with bleeding on probing.
KW - coronary artery disease
KW - gingival crevicular fluid
KW - interleukin-1β
KW - periodontal status
UR - http://www.scopus.com/inward/record.url?scp=85016084930&partnerID=8YFLogxK
U2 - 10.1063/1.4976773
DO - 10.1063/1.4976773
M3 - Conference contribution
AN - SCOPUS:85016084930
T3 - AIP Conference Proceedings
BT - Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Whulanza, Yudan
A2 - Supriadi, Sugeng
A2 - Sahlan, Muhamad
A2 - Basari, null
PB - American Institute of Physics Inc.
T2 - 1st International Symposium of Biomedical Engineering: Biomedical Engineering's Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2016
Y2 - 31 May 2016 through 1 June 2016
ER -