TY - JOUR
T1 - Level of Tumor Necrosis Factor Alpha in Elderly Patients with Periodontitis and Diabetes Mellitus
AU - Kurniati, Fonny
AU - Masulili, Sri Lelyati C.
AU - Haerani, Natalina
AU - Tadjoedin, Fatimah Maria
AU - Harsas, Nadhia Anindhita
AU - Soedarsono, Nurtami
AU - Wulandari, Pitu
N1 - Funding Information:
This research was sponsored by a Grant for International Publication Indexed for Student Final Project from the Directorate of Research and Community Engagement at Universitas Indonesia (HIBAH PITTA A 2019), Jakarta, Indonesia. The publication of this manuscript is supported by Universitas Indonesia.
Publisher Copyright:
© 2020. All Rights Reserved.
PY - 2020
Y1 - 2020
N2 - Periodontal diseases, such as periodontitis, have risk factors in common with other systemic and chronic inflammatory disorders. One inflammatory mediator that plays a role in the proinflammatory process is tumor necrosis factor a (TNF-α). With age, the body’s inflammatory responses change, and this is one reason why periodontitis is common among elderly patients. We compared TNF-α levels of 33 elderly patients with periodontitis who did not have diabetes with those of 18 elderly patients with both periodontitis and diabetes mellitus. Patients’ gingival crevicular fluid (GCF) was taken from sites with pocket depths of 5 to 6 mm, and their TNF-α levels were measured. Clinical data (pocket depth, bleeding index, and clinical attachment loss) and GCF samples were collected. Patients with diabetes had significantly higher Oral Health Information Suite indexes (3.1 ± 1.25) than did those without diabetes (2.17 ± 1.29; p < 0.05). Patients with diabetes had significantly higher TNF-a levels (5.04 ± 0.48) than did those without diabetes (4.67 ± 0.76; p < 0.05). Thus, the level of TNF-± is significantly higher in patients with diabetes than in those without.
AB - Periodontal diseases, such as periodontitis, have risk factors in common with other systemic and chronic inflammatory disorders. One inflammatory mediator that plays a role in the proinflammatory process is tumor necrosis factor a (TNF-α). With age, the body’s inflammatory responses change, and this is one reason why periodontitis is common among elderly patients. We compared TNF-α levels of 33 elderly patients with periodontitis who did not have diabetes with those of 18 elderly patients with both periodontitis and diabetes mellitus. Patients’ gingival crevicular fluid (GCF) was taken from sites with pocket depths of 5 to 6 mm, and their TNF-α levels were measured. Clinical data (pocket depth, bleeding index, and clinical attachment loss) and GCF samples were collected. Patients with diabetes had significantly higher Oral Health Information Suite indexes (3.1 ± 1.25) than did those without diabetes (2.17 ± 1.29; p < 0.05). Patients with diabetes had significantly higher TNF-a levels (5.04 ± 0.48) than did those without diabetes (4.67 ± 0.76; p < 0.05). Thus, the level of TNF-± is significantly higher in patients with diabetes than in those without.
KW - diabetes mellitus
KW - elderly
KW - periodontitis
KW - TNF-±
UR - http://www.scopus.com/inward/record.url?scp=85103517587&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85103517587
SN - 1309-100X
VL - 13
SP - 1461
EP - 1466
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 4
ER -
