Level of Tumor Necrosis Factor Alpha in Elderly Patients with Periodontitis and Diabetes Mellitus

Fonny Kurniati, Sri Lelyati C. Masulili, Natalina Haerani, Fatimah Maria Tadjoedin, Nadhia Anindhita Harsas, Nurtami Soedarsono, Pitu Wulandari

Research output: Contribution to journalArticlepeer-review

Abstract

Periodontal diseases, such as periodontitis, have risk factors in common with other systemic and chronic inflammatory disorders. One inflammatory mediator that plays a role in the proinflammatory process is tumor necrosis factor a (TNF-α). With age, the body’s inflammatory responses change, and this is one reason why periodontitis is common among elderly patients. We compared TNF-α levels of 33 elderly patients with periodontitis who did not have diabetes with those of 18 elderly patients with both periodontitis and diabetes mellitus. Patients’ gingival crevicular fluid (GCF) was taken from sites with pocket depths of 5 to 6 mm, and their TNF-α levels were measured. Clinical data (pocket depth, bleeding index, and clinical attachment loss) and GCF samples were collected. Patients with diabetes had significantly higher Oral Health Information Suite indexes (3.1 ± 1.25) than did those without diabetes (2.17 ± 1.29; p < 0.05). Patients with diabetes had significantly higher TNF-a levels (5.04 ± 0.48) than did those without diabetes (4.67 ± 0.76; p < 0.05). Thus, the level of TNF-± is significantly higher in patients with diabetes than in those without.

Original languageEnglish
Pages (from-to)1461-1466
Number of pages6
JournalJournal of International Dental and Medical Research
Volume13
Issue number4
Publication statusPublished - 2020

Keywords

  • diabetes mellitus
  • elderly
  • periodontitis
  • TNF-±

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