TY - JOUR
T1 - Level of calcitonin gene-related peptides in elderly and adult periodontitis patients
AU - Audrey, Anastasia
AU - Masulili, Sri Lelyati C.
AU - Sunarto, Hari
AU - Tadjoedin, Fatimah Maria
AU - Widaryono, Adit
AU - Wulandari, Pitu
AU - Auerkari, Elza Ibrahim
N1 - Publisher Copyright:
© 2020, University of Dicle.
PY - 2020
Y1 - 2020
N2 - Periodontitis is an inflammatory disease caused by bacteria that forms a dental biofilm. Calcitonin gene-related peptide (CGRP) is an anti-inflammatory agent that inhibits osteoclast activity. This study compared the CGRP levels in the gingival crevicular fluid (GCF) from adult and elderly periodontitis patients. Clinical samples were obtained from the GCF of 70 subjects with periodontal diseases, including male and female subjects 60-75 years old (n = 42) and control group adult patients 25-55 years old (n = 28). Measurements of clinical parameters, including the probing pocket depth (PPD) and bleeding on probing, were assessed as diagnostic criteria. A pocket depth was defined as being present if the PPD was ≥3 mm. An enzyme-linked immunosorbent assay was performed to measure the CGRP levels. The level of CGRP in the GCF was slightly higher in adult patients (39.91 pg/μg) than in elderly patients (25.52 pg/μg); however, this result was not statistically significant (p >.05). The level of CGRP in the GCF of periodontitis patients was not dependent on age and was lower in elderly patients.
AB - Periodontitis is an inflammatory disease caused by bacteria that forms a dental biofilm. Calcitonin gene-related peptide (CGRP) is an anti-inflammatory agent that inhibits osteoclast activity. This study compared the CGRP levels in the gingival crevicular fluid (GCF) from adult and elderly periodontitis patients. Clinical samples were obtained from the GCF of 70 subjects with periodontal diseases, including male and female subjects 60-75 years old (n = 42) and control group adult patients 25-55 years old (n = 28). Measurements of clinical parameters, including the probing pocket depth (PPD) and bleeding on probing, were assessed as diagnostic criteria. A pocket depth was defined as being present if the PPD was ≥3 mm. An enzyme-linked immunosorbent assay was performed to measure the CGRP levels. The level of CGRP in the GCF was slightly higher in adult patients (39.91 pg/μg) than in elderly patients (25.52 pg/μg); however, this result was not statistically significant (p >.05). The level of CGRP in the GCF of periodontitis patients was not dependent on age and was lower in elderly patients.
KW - Calcitonin
KW - Elderly
KW - Enzyme-linked immunosorbent assay
KW - Gingival crevicular fluid
KW - Periodontitis
UR - http://www.scopus.com/inward/record.url?scp=85092088149&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85092088149
SN - 1309-100X
VL - 13
SP - 1170
EP - 1173
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 3
ER -