Level of calcitonin gene-related peptides in elderly and adult periodontitis patients

Anastasia Audrey, Sri Lelyati C. Masulili, Hari Sunarto, Fatimah Maria Tadjoedin, Adit Widaryono, Pitu Wulandari, Elza Ibrahim Auerkari

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1 Citation (Scopus)


Periodontitis is an inflammatory disease caused by bacteria that forms a dental biofilm. Calcitonin gene-related peptide (CGRP) is an anti-inflammatory agent that inhibits osteoclast activity. This study compared the CGRP levels in the gingival crevicular fluid (GCF) from adult and elderly periodontitis patients. Clinical samples were obtained from the GCF of 70 subjects with periodontal diseases, including male and female subjects 60-75 years old (n = 42) and control group adult patients 25-55 years old (n = 28). Measurements of clinical parameters, including the probing pocket depth (PPD) and bleeding on probing, were assessed as diagnostic criteria. A pocket depth was defined as being present if the PPD was ≥3 mm. An enzyme-linked immunosorbent assay was performed to measure the CGRP levels. The level of CGRP in the GCF was slightly higher in adult patients (39.91 pg/μg) than in elderly patients (25.52 pg/μg); however, this result was not statistically significant (p >.05). The level of CGRP in the GCF of periodontitis patients was not dependent on age and was lower in elderly patients.

Original languageEnglish
Pages (from-to)1170-1173
Number of pages4
JournalJournal of International Dental and Medical Research
Issue number3
Publication statusPublished - 2020


  • Calcitonin
  • Elderly
  • Enzyme-linked immunosorbent assay
  • Gingival crevicular fluid
  • Periodontitis


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