Left ventricular end-diastolic volume index as a predictor of fluid responsiveness in children with shock

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Abstract

Objective: To identify the role of left ventricular end-diastolic volume index as a predictor of fluid responsiveness in children. Design: This was a diagnostic study in children with shock in the Emergency Room and Pediatric Intensive Care Unit of Cipto Mangunkusumo Hospital from June to November 2018. The left ventricular end-diastolic volume index measurements were performed using ultrasonic cardiac output monitor and compared to the increase in stroke volume of ≥15% after fluid challenge as fluid responsiveness criteria. Samples were categorized into fluid responsive and non-responsive. Results: Out of 40 subjects, 60 fluid challenge samples were obtained. There were 31 and 29 samples in the fluid responsive and non-responsive group, respectively. There was no significant difference in mean left ventricular end-diastolic volume index between the two groups (p=0.161). The area under the receiver operating characteristic (AUROC) of the left ventricular end-diastolic volume index was 40.9% with a cutoff value of 68.95 ml/m2. The sensitivity and specificity were 45.16% and 44.83%, respectively. At the left ventricular end-diastolic volume index value of 81.10 ml/m2, the specificity was 72.41% with 22.6% sensitivity. Conclusion: This study cannot justify the use of left ventricular end-diastolic volume index can act as a predictor of fluid responsiveness in children.

Original languageEnglish
Pages (from-to)125-135
Number of pages11
JournalCritical Care and Shock
Volume23
Issue number3
Publication statusPublished - 2020

Keywords

  • Fluid responsiveness
  • Hemodynamics
  • Left ventricular end-diastolic volume index
  • Shock

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