TY - JOUR
T1 - Lactobacillus plantarum IS-10506 probiotic administration increases amlodipine absorption in a rabbit model
AU - Saputri, Febrina A.
AU - Kang, Devinna
AU - Kusuma, Arif S.W.
AU - Rusdiana, Taofik
AU - Hasanah, Aliya N.
AU - Mutakin, Aliya N.
AU - Surono, Ingrid S.
AU - Koyama, Hiroshi
AU - Abdulah, Rizky
N1 - Funding Information:
This work was financially supported by The Indonesian Ministry of Research, Technology, and Higher Education (Grant-in-aid for International Research Collaboration and Publication) for RA.
Publisher Copyright:
© The Author(s) 2018.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Objective: Probiotics are beneficial in human health. In this study, we investigated the effect of probiotics on absorption of amlodipine, a dihydropyridine calcium antagonist used in the treatment of angina and hypertension, in a rabbit model. Methods: Lactobacillus plantarum IS-10506 probiotic was administered for 14 days to male New Zealand rabbits. Blood samples were collected before and after probiotic supplementation. Amlodipine (10 mg) was then administered to all groups. Blood samples from a marginal vein were withdrawn at 5, 15, 30, 60, and 120 minutes to determine amlodipine concentrations in rabbit plasma. Results: Amlodipine concentrations in the L. plantarum IS-10506 group were 4.95 ± 1.22, 8.71 ± 0.69, and 12.48 ± 2.53 ng/ml, and those in the control group were 1.69 ± 0.31, 3.89 ± 1.23, and 7.17 ± 1.85 ng/ml at 30, 60, and 120 minutes, respectively after administration of amlodipine. Amlodipine concentrations in the L. plantarum IS-10506 group were significantly higher than those in the control group at 30, 60, and 120 minutes after amlodipine administration. Conclusion: Our results suggested that supplementation of L. plantarum IS-10506 significantly increases amlodipine plasma concentrations in rabbits.
AB - Objective: Probiotics are beneficial in human health. In this study, we investigated the effect of probiotics on absorption of amlodipine, a dihydropyridine calcium antagonist used in the treatment of angina and hypertension, in a rabbit model. Methods: Lactobacillus plantarum IS-10506 probiotic was administered for 14 days to male New Zealand rabbits. Blood samples were collected before and after probiotic supplementation. Amlodipine (10 mg) was then administered to all groups. Blood samples from a marginal vein were withdrawn at 5, 15, 30, 60, and 120 minutes to determine amlodipine concentrations in rabbit plasma. Results: Amlodipine concentrations in the L. plantarum IS-10506 group were 4.95 ± 1.22, 8.71 ± 0.69, and 12.48 ± 2.53 ng/ml, and those in the control group were 1.69 ± 0.31, 3.89 ± 1.23, and 7.17 ± 1.85 ng/ml at 30, 60, and 120 minutes, respectively after administration of amlodipine. Amlodipine concentrations in the L. plantarum IS-10506 group were significantly higher than those in the control group at 30, 60, and 120 minutes after amlodipine administration. Conclusion: Our results suggested that supplementation of L. plantarum IS-10506 significantly increases amlodipine plasma concentrations in rabbits.
KW - absorption
KW - amlodipine
KW - calcium channel blocker
KW - dadih
KW - gastrointestinal tract
KW - hematology
KW - Lactobacillus plantarum
KW - Probiotic
UR - http://www.scopus.com/inward/record.url?scp=85058615649&partnerID=8YFLogxK
U2 - 10.1177/0300060518788994
DO - 10.1177/0300060518788994
M3 - Article
C2 - 30092663
AN - SCOPUS:85058615649
SN - 0300-0605
VL - 46
SP - 5004
EP - 5010
JO - Journal of International Medical Research
JF - Journal of International Medical Research
IS - 12
ER -
