TY - JOUR
T1 - Lactobacillus-derived bioactive metabolites for the regulation of periodontal health
T2 - Evidences to clinical setting
AU - Sulijaya, Benso
AU - Takahashi, Naoki
AU - Yamazaki, Kazuhisa
N1 - Funding Information:
This paper was financially supported in part by JSPS KAKENHI (Grant numbers 15H02578 and 18H04067 (to K.Y.) and 16H05554 (to N.T.)). The authors would like to acknowledge Jun Ogawa and Shigenobu Kishino from the Graduate School of Agriculture, Kyoto University, Japan, for providing the metabolites.
Funding Information:
to the published version of the manuscript. read, and approved the final article. Funding: This paper was financially supported in part by JSPS KAKENHI (Grant numbers 15H02578 and 18H04067Funding:(toThis paper was fK.Y.) and 16H05554inancially supp(to N.T.)). orted in part by JSPS KAKENHI (Grant numbers 15H02578 and 18H04067 (to K.Y.) and 16H05554 (to N.T.)). Acknowledgments: The authors would like to acknowledge Jun Ogawa and Shigenobu Kishino from the Graduate Acknowledgments: The authors would like to acknowledge Jun Ogawa and Shigenobu Kishino from the
Publisher Copyright:
© 2020 by the authors.
PY - 2020/5
Y1 - 2020/5
N2 - Background: Gut microbiota plays a pivotal role in regulating host metabolism that affects the systemic health. To date, several studies have confirmed the fact that microbiota interacts with host, modulating immunity, controlling the homeostasis environment, and maintaining systemic condition. Recent studies have focused on the protective function of poly unsaturated fatty acids, 10-oxo-trans-11-oxadecenoic acid (KetoC) and 10-hydroxy-cis-12-octadecenoic acid (HYA), generated by gut microbiota on periodontal disease. Nevertheless, the mechanism remains unclear as investigations are limited to in vivo and in vitro studies. In this present review, we found that the administration of metabolites, KetoC and HYA, by a probiotic gut microbiota Lactobacillus plantarum from linoleic acid is found to inhibit the oxidation process, possess an antimicrobial function, and prevent the inflammation. These findings suggest the promising use of functional lipids for human health. Conclusion: Protective modalities of bioactive metabolites may support periodontal therapy by suppressing bacterial dysbiosis and regulating periodontal homeostasis in the clinical setting.
AB - Background: Gut microbiota plays a pivotal role in regulating host metabolism that affects the systemic health. To date, several studies have confirmed the fact that microbiota interacts with host, modulating immunity, controlling the homeostasis environment, and maintaining systemic condition. Recent studies have focused on the protective function of poly unsaturated fatty acids, 10-oxo-trans-11-oxadecenoic acid (KetoC) and 10-hydroxy-cis-12-octadecenoic acid (HYA), generated by gut microbiota on periodontal disease. Nevertheless, the mechanism remains unclear as investigations are limited to in vivo and in vitro studies. In this present review, we found that the administration of metabolites, KetoC and HYA, by a probiotic gut microbiota Lactobacillus plantarum from linoleic acid is found to inhibit the oxidation process, possess an antimicrobial function, and prevent the inflammation. These findings suggest the promising use of functional lipids for human health. Conclusion: Protective modalities of bioactive metabolites may support periodontal therapy by suppressing bacterial dysbiosis and regulating periodontal homeostasis in the clinical setting.
KW - Fatty acid
KW - Gut bacteria
KW - Metabolite
KW - Periodontal disease
UR - http://www.scopus.com/inward/record.url?scp=85083885466&partnerID=8YFLogxK
U2 - 10.3390/molecules25092088
DO - 10.3390/molecules25092088
M3 - Review article
C2 - 32365716
AN - SCOPUS:85083885466
SN - 1420-3049
VL - 25
JO - Molecules
JF - Molecules
IS - 9
M1 - 2088
ER -
