KESESUAIAN AKTIVITAS EPILEPTIFORM DAN LOKASI TUMOR PRIMER INTRAKRANIAL PADA MRI DENGAN KLINIS BANGKITAN

Introduction: Seizure is a common symptom of primary intracranial tumors and the main cause of morbidity. Electroencephalography (EEG) examination is required to determine the concordance of seizure foci with the tumor location on MRI that will determine the prognosis of seizures. Many factors affect the concordance of the seizure foci with tumor location. Aims: To determine the concordance of epileptiform activity on EEG and tumor locations on MRI in patients with primary intracranial tumors with clinical seizures. Methods: This was a cross-sectional retrospective study using medical records of patients with suspicion of primary intracranial tumors presenting with clinical seizures in Cipto Mangunkusumo hospital from August 2013 to April 2014. Patients with complete clinical data, MRI, and EEG findings were included. Results: From 33 subjects with primary intracranial tumors with clinical seizures, only 17 (51.5%) subjects showed epileptiform activity on EEG recording. All patients experienced partial seizures with secondary generalized seizures as the most common type (94.1%). Most seizures were found in frontal lobe tumors (64.7%) and the most common tumor type was low-grade astrocytoma (47.1%). The concordance of epileptiform activity with tumor location was found in 47.1% subjects with a predominant location in temporal lobe. Discussion: Most of the focus location was not in concordance with tumor location on MRI. This could be caused by secondary epileptogenesis or complications that arose during the course of the disease such as pain, metabolic disorders, and complications of treatment.