Kefektifan Sedasi antara Campuran Ketamin Propofol (Ketofol), dan Propofol Fentanil pada Prosedur Endoscopic Retrograde Cholangiopancreatography (ERCP)

Adhrie Sugiarto, Aries Perdana, Norman Rabker Jefrey Tuhulele

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The effectiveness of sedation is the ability of the drugs to maintain sedation depth and analgesia, and to controlpatients movements during ERCP procedure. Propofol is a sedative agent that has no analgesia effect and hasa dose-dependent cardiovascular and respiratory depressant effects. The addition of small dose of ketamin isexpected to reduce the required dose to maintain hemodinamic and respiratory stability. This study comparedthe effectiveness of sedation between 1:4 ketamin propofol mixtures (ketofol) and propofol-fentanyl in ERCPprocedure. This research a double blind randomised clinical trial was done in 36 adult patients who underwentERCP procedure, which were divided into two groups: KF group (n = 18), which were treated with ketofol 1:4in a 50 mL syringe, and PF group (n = 18) which were treated with fentanil 1 mcg/kgBW and propofol in a 50mL syringe. The depth of sedation was measured by Ramsay Sedation Scale (RSS). The average consumption ofpropofol per minute of ketofol group was significantly lower than fentanyl propofol group (p<0.05). The medianfentanyl consumption of ketofol group was significantly lower than fentanyl propofol group (p<0.05). The onsetand the recovery time in fentanyl propofol group were faster than ketofol group (p<0.05). There was no significantdifferent in the incidence of hypotension in both groups (p>0.05). There were no desaturation events or nausea/vomiting in both groups. Conclution ketofol was more effective than fentanyl-propofol mixture in maintaining thedepth of sedation and analgesia and has minimal side effects.
Original languageIndonesian
Publication statusPublished - 2016

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