Isolation, Identification and Synthesis of Neolignans from Phoebe declinata Leaves: Molecular Modeling and Anticancer Evaluation

Keyphrases

• Methanol 100%
• Evaluation Model 100%
• Phoebe 100%
• Molecular Modeling 100%
• Neolignan 100%
• Anticancer Evaluation 100%
• 13C NMR 66%
• Dichloromethane 66%
• Reducing Agent 33%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 33%
• Mobile Phase 33%
• Molecular Structure 33%
• IC50 33%
• Acetyl 33%
• Binding Affinity 33%
• Estrogen Receptor 1 (ESR1) 33%
• High Activity 33%
• 1H nuclear Magnetic Resonance (1H NMR) 33%
• Breast Cancer Cell Lines 33%
• N-hexane 33%
• Acetic Anhydride 33%
• Stationary Phase 33%
• NaBH4 33%
• MCF-7 33%
• Cytotoxic Activity 33%
• MCF-7 Cells 33%
• Cancer Drugs 33%
• Structure Identification 33%
• Doxorubicin 33%
• Structure-activity Relationship 33%
• Plant Leaves 33%
• 2D NMR 33%
• Lauraceae 33%
• Silica Column Chromatography 33%
• 2D-LC 33%
• ADME Properties 33%
• Membrane Estrogen Receptor 33%
• In Vitro Antiproliferative Activity 33%

Chemistry

• Methanol 100%
• Dichloromethane 100%
• Neolignan 100%
• Inhibition Constant (Ki) 100%
• Molecular Model 100%
• Silicon Dioxide 50%
• Mobile Phase Composition 50%
• Liquid Chromatography Mass Spectrometry 50%
• Acetyl 50%
• Column Chromatography 50%
• 1H NMR Spectroscopy 50%
• IC50 50%
• Molecular Structure 50%
• Molecular Mass 50%
• Reducing Agent 50%
• 13C NMR Spectroscopy 50%
• Cancer Drug 50%
• Hexane 50%
• Kd 50%
• Structure-Activity Relationship 50%
• Acetic Anhydride 50%
• Two-Dimensional NMR 50%
• Antiproliferative 50%
• Doxorubicin 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Methanol 100%
• Dichloromethane 100%
• Neolignan 100%
• Breast Cancer 50%
• Malignant Neoplasm 50%
• Reducing Agent 50%
• Silicon Dioxide 50%
• Antiproliferative Activity 50%
• IC50 50%
• Estrogen Receptor Alpha 50%
• Hexane 50%
• Doxorubicin 50%
• Sodium Borohydride 50%
• Carbon 13 50%
• Absorption Distribution Metabolism Excretion 50%
• Structure Activity Relationship 50%
• Acetic Acid Derivative 50%
• Acetic Anhydride 50%
• Lauraceae 50%
• Cytotoxicity 50%