Isolation, characterization and antidiabetic activity of phenolic compounds isolated from macaranga magna turrill

Minarti, A. H. Cahyana, A. Darmawan

Research output: Contribution to journalArticlepeer-review

Abstract

Southeast Sulawesi is an Indonesian region that has a large amount of biodiversity resources. As part of our continuous drug discovery project, three phenolic compounds, namely (1) scopoletin, (2) apigenin, and (3) gallic acid were successfully isolated from the leaf extract of Macaranga magna Turrill. The isolation and purification processes were conducted by serial chromatography, and their chemical structures were elucidated on the basis of spectroscopic data (FT-IR, FT-NMR and LC-ESI-MS), as well as through data comparison with the related body of literature. Their potential antidiabetic activity was evaluated against α-glucosidase enzymes. Scopoletin showed the highest antidiabetic activity compared to apigenin and gallic acid, with IC50 values of 91.7, 28.3, and 198.5 μg/mL, respectively.

Original languageEnglish
Pages (from-to)2420-2427
Number of pages8
JournalRasayan Journal of Chemistry
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Oct 2021

Keywords

  • Antidiabetic
  • Apigenin
  • Gallic acid
  • Macaranga magna turrill
  • Scopoletin
  • α-glucosidase

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