TY - JOUR
T1 - Isolation, characterization and antidiabetic activity of phenolic compounds isolated from macaranga magna turrill
AU - Minarti,
AU - Cahyana, A. H.
AU - Darmawan, A.
N1 - Publisher Copyright:
© 2021, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Southeast Sulawesi is an Indonesian region that has a large amount of biodiversity resources. As part of our continuous drug discovery project, three phenolic compounds, namely (1) scopoletin, (2) apigenin, and (3) gallic acid were successfully isolated from the leaf extract of Macaranga magna Turrill. The isolation and purification processes were conducted by serial chromatography, and their chemical structures were elucidated on the basis of spectroscopic data (FT-IR, FT-NMR and LC-ESI-MS), as well as through data comparison with the related body of literature. Their potential antidiabetic activity was evaluated against α-glucosidase enzymes. Scopoletin showed the highest antidiabetic activity compared to apigenin and gallic acid, with IC50 values of 91.7, 28.3, and 198.5 μg/mL, respectively.
AB - Southeast Sulawesi is an Indonesian region that has a large amount of biodiversity resources. As part of our continuous drug discovery project, three phenolic compounds, namely (1) scopoletin, (2) apigenin, and (3) gallic acid were successfully isolated from the leaf extract of Macaranga magna Turrill. The isolation and purification processes were conducted by serial chromatography, and their chemical structures were elucidated on the basis of spectroscopic data (FT-IR, FT-NMR and LC-ESI-MS), as well as through data comparison with the related body of literature. Their potential antidiabetic activity was evaluated against α-glucosidase enzymes. Scopoletin showed the highest antidiabetic activity compared to apigenin and gallic acid, with IC50 values of 91.7, 28.3, and 198.5 μg/mL, respectively.
KW - Antidiabetic
KW - Apigenin
KW - Gallic acid
KW - Macaranga magna turrill
KW - Scopoletin
KW - α-glucosidase
UR - http://www.scopus.com/inward/record.url?scp=85119612316&partnerID=8YFLogxK
U2 - 10.31788/RJC.2021.1446290
DO - 10.31788/RJC.2021.1446290
M3 - Article
AN - SCOPUS:85119612316
SN - 0974-1496
VL - 14
SP - 2420
EP - 2427
JO - Rasayan Journal of Chemistry
JF - Rasayan Journal of Chemistry
IS - 4
ER -