Is Tissue Oxygenation Causes Jaw Osteonecrosis in Osteoporotic Bone?

Anggraeny Putri Sekar Palupi, Benny Sjariefsjah Latief, Bambang Pontjo Priosoeryanto, Dewi Fatma Suniarti, Tri Isyani Tungga Dewi

Research output: Contribution to journalArticlepeer-review


The pathogenesis of the occurrence of BRONJ until now cannot be determined with certainty. This paper investigates the effects of zoledronic acid (Z) on tissue oxygenation concerning the healing process of post-extraction tooth sockets. 24 female Sprague Dawley mice that had an ovariectomy were divided into three groups: a dose of 1x Z (n=8), a group of 6x Z (n=8), and a control group (n=8) who got 0.1mg/kg of Z through the intravena pathway. After six weeks, the extraction of the first molar teeth of the mandible. IHK and Elisa examinations were carried out on H+0 and H+14 post-extraction to observe HIF1-alpha, BMP2, and VWF expression concentrations. Statistical analysis results using the Kruskal-Wallis nonparametric test, the concentration of HIF1-alpha did not get a significant difference (p = 0.073). Likewise for the concentration of BMP2 (p = 0.123). As for the expression of also found no significant results (p = 0.076). The concentrations of HIF1-alpha and BMP2 tended to be higher in the Z group, although the results were not statistically significant. For VWF expression, the higher trend in the Z group was statistically insignificant. Therefore, caution is needed when interpreting the results of these three types of analysis with follow-up research dan clinical studies.

Original languageEnglish
Pages (from-to)1001-1005
Number of pages5
JournalJournal of International Dental and Medical Research
Issue number3
Publication statusPublished - 2022


  • Bone morphogenetic proteins
  • Hypoxia-inducible factor 1
  • Osteonecrosis
  • Zoledronic acid


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