Iron absorption in iron-deficient women, who received 65 mg Fe with an Indonesian breakfast, is much better from naFe(III)EDTA than from Fe(II)SO4, with an acceptable increase of plasma NTBI. A randomized clinical trial

Eka Ginanjar, Lilik Indrawati, Iswari Setianingsih, Djumhana Atmakusumah, Alida Harahap, Ina S. Timan, Joannes J.M. Marx

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4 Citations (Scopus)

Abstract

Plasma non-transferrin-bound iron (NTBI) is potentially harmful due to the generation of free radicals that cause tissue damage in vascular and other diseases. Studies in iron-replete and iron-deficient subjects, receiving a single oral test dose of Fe(II)SO4 or NaFe(III)EDTA with water, revealed that FeSO4 was well absorbed when compared with NaFeEDTA, while only the Fe(II) compound showed a remarkable increase of NTBI. As NaFeEDTA is successfully used for food fortification, a double-blind randomized cross-over trial was conducted in 11 healthy women with uncomplicated iron deficiency. All subjects received a placebo, 6.5 mg FeSO4, 65 mg FeSO4, 6.5 mg NaFeEDTA, and 65 mg NaFeEDTA with a traditional Indonesian breakfast in one-week intervals. Blood tests were carried out every 60 min for five hours. NTBI detection was performed using the fluorescein-labeled apotransferrin method. Plasma iron values were highly increased after 65 mg NaFeEDTA, twice as high as after FeSO4. A similar pattern was seen for NTBI. After 6.5 mg of NaFeEDTA and FeSO4, NTBI was hardly detectable. NaFeEDTA was highly effective for the treatment of iron deficiency if given with a meal, inhibiting the formation of nonabsorbable Fe-complexes, while NTBI did not exceed the range of normal values for iron-replete subjects.

Original languageEnglish
Article number85
JournalPharmaceuticals
Volume11
Issue number3
DOIs
Publication statusPublished - Sep 2018

Keywords

  • Developing countries
  • FeSO
  • Indonesia
  • Iron deficiency anemia
  • NaFeEDTA
  • Non-transferrin-bound iron (NTBI)
  • Nutrient iron
  • Oral iron therapy

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