TY - JOUR
T1 - Iodine-catalyzed Synthesis, Antibacterial, and Antioxidant Activity of Isatin Derivatives
AU - Cahyana, Antonius Herry
AU - Liandi, Agus Rimus
AU - Ongkowidjawa, Yosua
N1 - Publisher Copyright:
© 2024, Gadjah Mada University. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Isatin is a unique compound with many bioactivities such as antiviral, antiHIV, antitumor, anti-inflammatory, anticonvulsant, and antifungal. In this study, isatin derivatives were synthesized with an iodine catalyst and tested for antibacterial and antioxidant activities. Isatin derivatives were conducted through a Knoevenagel condensation reaction between isatin and malononitrile. The products were confirmed by thin-layer chromatography, melting point apparatus, FTIR, UV-vis spectroscopy, and LC-MS. The optimum reaction conditions were obtained at 10% mol of catalyst, at boiling point ethanol solvent for 30 min. The yield of the isatin derivative products was 71% (3a), 61% (3b), and 67% (3c). The antibacterial activities of the synthesized compounds were weak activity against S. aureus and E. coli. The antioxidant activity test resulted in IC50 values of 266.47, 220.43, and 654.85 ppm for compounds 3a, 3b, and 3c, respectively. The synthesis method using an iodine catalyst in this reaction offers a higher product yield compared to a catalyst-free reaction.
AB - Isatin is a unique compound with many bioactivities such as antiviral, antiHIV, antitumor, anti-inflammatory, anticonvulsant, and antifungal. In this study, isatin derivatives were synthesized with an iodine catalyst and tested for antibacterial and antioxidant activities. Isatin derivatives were conducted through a Knoevenagel condensation reaction between isatin and malononitrile. The products were confirmed by thin-layer chromatography, melting point apparatus, FTIR, UV-vis spectroscopy, and LC-MS. The optimum reaction conditions were obtained at 10% mol of catalyst, at boiling point ethanol solvent for 30 min. The yield of the isatin derivative products was 71% (3a), 61% (3b), and 67% (3c). The antibacterial activities of the synthesized compounds were weak activity against S. aureus and E. coli. The antioxidant activity test resulted in IC50 values of 266.47, 220.43, and 654.85 ppm for compounds 3a, 3b, and 3c, respectively. The synthesis method using an iodine catalyst in this reaction offers a higher product yield compared to a catalyst-free reaction.
KW - antibacterial
KW - antioxidant
KW - iodine catalyst
KW - isatin
KW - Knoevenagel condensation reaction
UR - http://www.scopus.com/inward/record.url?scp=85191745537&partnerID=8YFLogxK
U2 - 10.22146/ijc.84113
DO - 10.22146/ijc.84113
M3 - Article
AN - SCOPUS:85191745537
SN - 1411-9420
VL - 24
SP - 567
EP - 575
JO - Indonesian Journal of Chemistry
JF - Indonesian Journal of Chemistry
IS - 2
ER -