Untersuchung der bildgebenden Eigenschaften des ALBIRA II Kleintier-PET-Systems für 18F, 68Ga und 64Cu

Translated title of the contribution: Investigation of the imaging characteristics of the ALBIRA II small animal PET system for 18F, 68Ga and 64Cu

Ali Asgar Attarwala, Yvonne Wanjiku Karanja, Deni Hardiansyah, Chiara Romanó, Mareike Roscher, Björn Wängler, Gerhard Glatting

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Aim In this study the performance characteristics of the Albira II PET sub-system and the response of the system for the following radionuclides 18F, 68Ga and 64Cu was analyzed. Materials and methods The Albira II tri-modal system (Bruker BioSpin MRI GmbH, Ettlingen, Germany) is a pre-clinical device for PET, SPECT and CT. The PET sub-system uses single continuous crystal detectors of lutetium yttrium orthosilicate (LYSO). The detector assembly consists of three rings of 8 detector modules. The transaxial field of view (FOV) has a diameter of 80 mm and the axial FOV is 148 mm. A NEMA NU-4 image quality phantom (Data Spectrum Corporation, Durham, USA) having five rods with diameters of 1, 2, 3, 4 and 5 mm and a uniform central region was used. Measurements with 18F, 68Ga and 64Cu were performed in list mode acquisition over 10 h. Data were reconstructed using a maximum-likelihood expectation-maximization (MLEM) algorithm with iteration numbers between 5 and 50. System sensitivity, count rate linearity, convergence and recovery coefficients were analyzed. Results The sensitivities for the entire FOV (non-NEMA method) for 18F, 68Ga and 64Cu were (3.78 ± 0.05)%, (3.97 ± 0.18)% and (3.79 ± 0.37)%, respectively. The sensitivity based on the NEMA protocol using the 22Na point source yielded (5.53 ± 0.06)%. Dead-time corrected true counts were linear for activities ≤7 MBq (18F and 68Ga) and ≤17 MBq (64Cu) in the phantom. The radial, tangential and axial full widths at half maximum (FWHMs) were 1.52, 1.47 and 1.48 mm. Recovery coefficients for the uniform region with a total activity of 8 MBq in the phantom were (0.97 ± 0.05), (0.98 ± 0.06), (0.98 ± 0.06) for 18F, 68Ga and 64Cu, respectively. Conclusion The Albira II pre-clinical PET system has an adequate sensitivity range and the system linearity is suitable for the range of activities used for pre-clinical imaging. Overall, the system showed a favorable image quality for pre-clinical applications.

Translated title of the contributionInvestigation of the imaging characteristics of the ALBIRA II small animal PET system for 18F, 68Ga and 64Cu
Original languageGerman
Pages (from-to)132-144
Number of pages13
JournalZeitschrift fur Medizinische Physik
Volume27
Issue number2
DOIs
Publication statusPublished - Jun 2017

Keywords

  • PET isotopes
  • Positron emission tomography (PET)
  • pre-clinical imaging
  • recovery coefficients

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