Investigating the Effects of Hydro-alcoholic Urtica Dioica Extract and Retinoic Acid on Follicular Development: An Animal Study

Saade Abdalkareem Jasim, Sana Abdul Jabbar Ali, Osama Q. Fadhil, Muqaddas Kh Rakhmatova, Hamzah H. Kzar, Ria Margiana, Moaed E. Al-Gazally, Abduladheem Turki Jalil, Zaid Hameed Mahmood, Surendar Aravindhan, Yasser Fakri Mustafa, Mohammed Q. Sultan

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background: Urtica dioica (UD), as a natural antioxidant, has positive effects on oocyte maturation. This study aimed to investigate the effects of hydro-alcoholic UD extract and retinoic acid on follicular development in an in vitro fertilization (IVF) condition. Methods: A total of 40 female Wistar rats were randomly divided into 5 groups: group 1 received normal saline, group 2 was given 25 mg/kg retinoic acid, group 3 was administered with 100 mg/kg UD extract, group 4 was treated with retinoic acid plus UD extract, and group 5 received 10 mg/kg olive oil. The histomorphometric parameters were analyzed, including the number of follicles, follicular atrophy, fertilized oocytes, 2-cell embryos, dead embryos, and blastocysts. Results: Retinoic acid caused a significant increase in the primary, preantral, and atretic follicles and a substantial decrease in the corpus luteum compared with the control group (p<0.001). The number of preantral, antral follicles, and corpus luteum was significantly higher in group 3 compared with group 1 (p<0.001). Moreover, coadministration of UD plus retinoic acid (group 4) significantly reduced the atretic follicles (p<0.05).

Original languageEnglish
Article number1
JournalMedical Journal of the Islamic Republic of Iran
Volume37
Issue number1
DOIs
Publication statusPublished - 2023

Keywords

  • Fertilization
  • Histology
  • Phytomedicine
  • Retinoic Acid
  • Urtica Dioica

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