Intra-breath-hold residual motion of image-guided DIBH liver-SBRT: An estimation by ultrasound-based monitoring correlated with diaphragm position in CBCT

Lena Vogel, Dwi Seno Kuncoro Sihono, Christel Weiss, Frank Lohr, Florian Stieler, Hansjörg Wertz, Sandra von Swietochowski, Anna Simeonova-Chergou, Frederik Wenz, Manuel Blessing, Judit Boda-Heggemann

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Background and purpose: Craniocaudal motion during image-guided abdominal SBRT can be reduced by computer-controlled deep-inspiratory-breath-hold (DIBH). However, a residual motion can occur in the DIBH-phases which can only be detected with intrafractional real-time-monitoring. We assessed the intra-breath-hold residual motion of DIBH and compared residual motion of target structures during DIBH detected by ultrasound (US). US data were compared with residual motion of the diaphragm-dome (DD) detected in the DIBH-CBCT-projections. Patients and methods: US-based monitoring was performed with an experimental US-system simultaneously to DIBH-CBCT acquisition. A total of 706 DIBHs during SBRT-treatments of metastatic lesions (liver, spleen, adrenal) of various primaries were registered in 13 patients. Residual motion of the target structure was documented with US during each DIBH. Motion of the DD was determined by comparison to a reference phantom-scan taking the individual geometrical setting at a given projection angle into account. Residual motion data detected by US were correlated to those of the DD (DIBH-CBCT-projection). Results: US-based monitoring could be performed in all cases and was well tolerated by all patients. Additional time for daily US-based setup required 8 ± 4 min. 385 DIBHs of 706 could be analyzed. In 59% of all DIBHs, residual motion was below 2 mm. In 36%, residual motion of 2–5 mm and in 4% of 5–8 mm was observed. Only 1% of all DIBHs and 0.16% of all readings revealed a residual motion of >8 mm during DIBH. For DIBHs with a residual motion over 2 mm, 137 of 156 CBCT-to-US curves had a parallel residual motion and showed a statistical correlation. Discussion and conclusion: Soft-tissue monitoring with ultrasound is a fast real-time method without additional radiation exposure. Computer-controlled DIBH has a residual motion of <5 mm in >95% which is in line with the published intra-breath-hold-precision. Larger intrafractional deviations can be avoided if the beam is stopped at an US-defined threshold.

Original languageEnglish
Pages (from-to)441-448
Number of pages8
JournalRadiotherapy and Oncology
Volume129
Issue number3
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • CBCT
  • DIBH
  • Diaphragm motion
  • Real-time monitoring
  • SBRT
  • Ultrasound

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