Interpretation of human tooth nerve fiber image: Nodes of ranvier and sodium channel Nav1.8 detection using local enhancement and normalization techniques

Muhammad Rabindra Surya, Mellawaty Rusdi, Aniati Murni Arymurthy, Siti Mardewi Soerono-Akbar, Didi Nugroho Santosa

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Tooth pain is the most common form of orofacial pain. Tooth sensory system is very sensitive to detect noxious stimulus. Most of sensory stimulus, which come from pulp afferent fibres will cause pain sensation. Action potential transmits the stimulus from periphery to the central. Sodium channels have an important role to generate and propagate the action potential. One of its isoforms, Nav1.8, has only found in sensory nerve, especially in nociceptive neuron that deliver pain stimulus. In myelinated neuron such as A-δ fibres, sodium channels located in high density on the node of Ranvier. The density of sodium channel Nav1.8 has a strong relation with tooth sensitivity. We implement method to detect nodes of Ranvier and detect Nav1.8 as our region of interest. In this paper, threshold and local enhancement is used for nodes of Ranvier detection and improvement of Euclidean path for sodium channels Nav1.8 detection.

Original languageEnglish
Title of host publication5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011
DOIs
Publication statusPublished - 14 Jul 2011
Event5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011 - Wuhan, China
Duration: 10 May 201112 May 2011

Publication series

Name5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011

Conference

Conference5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011
CountryChina
CityWuhan
Period10/05/1112/05/11

Keywords

  • Detection
  • Fluorescent
  • Fusion
  • Nodes of Ranvier
  • Paranodes

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