Periodontitis is a multifactorial disease and is strongly associated with systemic disease. IL-6R gene is one of the genes that have been proven in previous studies have a role in the development of periodontitis. The differences in the genetic role between populations became the basis of this study. This study aimed to assess the description and distribution of IL-6R A/C gene polymorphism in periodontitis patients. This study was a descriptive study with cross sectional research design. The number of samples used amounted to 100 samples consisting of 50 periodontitis samples and 50 control samples. IL-6R A/C gene polymorphism was analyzed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique using HinfI enzyme. In this study, there was IL-6R A/C gene polymorphism in periodontitis patients. The result showed AA genotype 8%, AC genotype 32%, CC genotype 60%, with C-allele frequency of 76% in periodontitis patients. The majority of the research samples and control samples had polymorphic genotypes with a higher number of polymorphic alleles in control samples (81%) than in the study sample (76%). It can be concluded that IL-6R A/C gene polymorphism was found in periodontitis patient.