TY - GEN
T1 - Interleukin-6 receptor (IL-6R) +48892 a/c (rs8192284) gene polymorphism in periodontitis patients
AU - Fionica, Selvia Arowanasari
AU - Soekanto, Sri Angky
AU - Suhartono, Winoto A.
AU - Bawazier, Shafa Ahmad
AU - Auerkari, Elza Ibrahim
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/4/9
Y1 - 2019/4/9
N2 - Periodontitis is a multifactorial disease and is strongly associated with systemic disease. IL-6R gene is one of the genes that have been proven in previous studies have a role in the development of periodontitis. The differences in the genetic role between populations became the basis of this study. This study aimed to assess the description and distribution of IL-6R A/C gene polymorphism in periodontitis patients. This study was a descriptive study with cross sectional research design. The number of samples used amounted to 100 samples consisting of 50 periodontitis samples and 50 control samples. IL-6R A/C gene polymorphism was analyzed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique using HinfI enzyme. In this study, there was IL-6R A/C gene polymorphism in periodontitis patients. The result showed AA genotype 8%, AC genotype 32%, CC genotype 60%, with C-allele frequency of 76% in periodontitis patients. The majority of the research samples and control samples had polymorphic genotypes with a higher number of polymorphic alleles in control samples (81%) than in the study sample (76%). It can be concluded that IL-6R A/C gene polymorphism was found in periodontitis patient.
AB - Periodontitis is a multifactorial disease and is strongly associated with systemic disease. IL-6R gene is one of the genes that have been proven in previous studies have a role in the development of periodontitis. The differences in the genetic role between populations became the basis of this study. This study aimed to assess the description and distribution of IL-6R A/C gene polymorphism in periodontitis patients. This study was a descriptive study with cross sectional research design. The number of samples used amounted to 100 samples consisting of 50 periodontitis samples and 50 control samples. IL-6R A/C gene polymorphism was analyzed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism technique using HinfI enzyme. In this study, there was IL-6R A/C gene polymorphism in periodontitis patients. The result showed AA genotype 8%, AC genotype 32%, CC genotype 60%, with C-allele frequency of 76% in periodontitis patients. The majority of the research samples and control samples had polymorphic genotypes with a higher number of polymorphic alleles in control samples (81%) than in the study sample (76%). It can be concluded that IL-6R A/C gene polymorphism was found in periodontitis patient.
KW - Gene polymorphism
KW - Interleukin-6 Receptor (IL-6R)
KW - periodontitis patients
UR - http://www.scopus.com/inward/record.url?scp=85064831388&partnerID=8YFLogxK
U2 - 10.1063/1.5096757
DO - 10.1063/1.5096757
M3 - Conference contribution
AN - SCOPUS:85064831388
T3 - AIP Conference Proceedings
BT - 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Wulan, Praswasti P.D.K.
A2 - Gozan, Misri
A2 - Astutiningsih, Sotya
A2 - Ramahdita, Ghiska
A2 - Dhelika, Radon
A2 - Kreshanti, Prasetyanugraheni
PB - American Institute of Physics Inc.
T2 - 3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
Y2 - 6 August 2018 through 8 August 2018
ER -