TY - JOUR
T1 - Interleukin-6-174 G/C genetic polymorphism in indonesian postmenopausal women
AU - Prasetyo, Sri Redjeki
AU - Saraswati, Eliza
AU - Hutabarat, Astrid Dinda Renata
AU - Djamal, Niniarty
AU - Puspitawati, Ria
AU - Kusdhany, Lindawati
AU - Auerkari, Elza Ibrahim
N1 - Publisher Copyright:
© 2017, University of Dicle.
PY - 2017
Y1 - 2017
N2 - Osteoporosis is a multifactorial disease with a recognized, but not well defined, genetic component. Many contributing candidate genes have a role in bone metabolism, such as the gene encoding for interleukin-6 (IL-6). Previous work on the relationship between IL-6 with osteoporosis suggested that IL-6 can increase the number of osteoclasts and lead to lower bone mass density (BMD). However, the influence of IL-6 -G174C polymorphism on postmenopausal women with osteoporotic risk still needs further research. The aim of this study was to examine the relationship between the Interleukin-6 -G174C gene polymorphism and osteoporosis risk in postmenopausal women. We collected 100 blood samples from postmenopausal Indonesian women (23 with normal BMD and 77 with osteoporosis) for analysis using PCR-RFLP with the NlaIII enzyme. The results showed that 96 (96%) of the subjects in the study population carried the GG genotype, 4 (4%) had the GC genotype, and none had the CC genotype. No significant association was determined between osteoporosis risk in postmenopausal women and IL-6 -G174C polymorphism (Fisher test, p= 0.571).
AB - Osteoporosis is a multifactorial disease with a recognized, but not well defined, genetic component. Many contributing candidate genes have a role in bone metabolism, such as the gene encoding for interleukin-6 (IL-6). Previous work on the relationship between IL-6 with osteoporosis suggested that IL-6 can increase the number of osteoclasts and lead to lower bone mass density (BMD). However, the influence of IL-6 -G174C polymorphism on postmenopausal women with osteoporotic risk still needs further research. The aim of this study was to examine the relationship between the Interleukin-6 -G174C gene polymorphism and osteoporosis risk in postmenopausal women. We collected 100 blood samples from postmenopausal Indonesian women (23 with normal BMD and 77 with osteoporosis) for analysis using PCR-RFLP with the NlaIII enzyme. The results showed that 96 (96%) of the subjects in the study population carried the GG genotype, 4 (4%) had the GC genotype, and none had the CC genotype. No significant association was determined between osteoporosis risk in postmenopausal women and IL-6 -G174C polymorphism (Fisher test, p= 0.571).
KW - BMD
KW - IL-6 Polymorphism
KW - Indonesia
KW - Postmenopausal women
UR - http://www.scopus.com/inward/record.url?scp=85050197885&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85050197885
SN - 1309-100X
VL - 10
SP - 707
EP - 710
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - Specialissue
ER -