Interleukin-6-174 G/C genetic polymorphism in indonesian postmenopausal women

Osteoporosis is a multifactorial disease with a recognized, but not well defined, genetic component. Many contributing candidate genes have a role in bone metabolism, such as the gene encoding for interleukin-6 (IL-6). Previous work on the relationship between IL-6 with osteoporosis suggested that IL-6 can increase the number of osteoclasts and lead to lower bone mass density (BMD). However, the influence of IL-6 -G174C polymorphism on postmenopausal women with osteoporotic risk still needs further research. The aim of this study was to examine the relationship between the Interleukin-6 -G174C gene polymorphism and osteoporosis risk in postmenopausal women. We collected 100 blood samples from postmenopausal Indonesian women (23 with normal BMD and 77 with osteoporosis) for analysis using PCR-RFLP with the NlaIII enzyme. The results showed that 96 (96%) of the subjects in the study population carried the GG genotype, 4 (4%) had the GC genotype, and none had the CC genotype. No significant association was determined between osteoporosis risk in postmenopausal women and IL-6 -G174C polymorphism (Fisher test, p= 0.571).