Interleukin-18 levels in adult dengue fever and dengue hemorrhagic fever

Herdiman T. Pohan; Rika Bur; Asnath Matondang; Samsuridjal Djauzi; Katsuya Inada; Shigeatsu Endo

doi:10.13181/mji.v13i2.136

Interleukin-18 levels in adult dengue fever and dengue hemorrhagic fever

Herdiman T. Pohan, Suhendro, Rika Bur, Asnath Matondang, Samsuridjal Djauzi, Katsuya Inada, Shigeatsu Endo

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Interleukin (IL)-18 (interferon-γ inducing factor) is one of cytokines, produced by macrophage, take part in differentiation T-helper (Th) to Th1 and interferon γ producing. T-helper1 play role in cellular immunity especially in viral infection include dengue. A descriptive correlative study has done to know the correlation between IL-18 levels and disease severity in admitted dengue fever (DF) and dengue hemorrhagic fever (DHF) patients. In 42 subjects consist of 20 (47.6%) DF and 22 (53.3%) DHF (grade I to IV WHO criteria, 1999) showed that IL-18 levels significantly higher in DHF than DF patients. There are significant correlation between IL-18 levels and hematocrit and low platelet value. This study supports the possible role of IL-18 in pathogenesis DHF in adults.

Original language	English
Pages (from-to)	86-89
Number of pages	4
Journal	Medical Journal of Indonesia
Volume	13
Issue number	2
DOIs	https://doi.org/10.13181/mji.v13i2.136
Publication status	Published - 1 Apr 2004

Keywords

Cytokine
Dengue
Dengue hemorrhagic fever
IL-18
Pathogenesis

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abstract = "Interleukin (IL)-18 (interferon-γ inducing factor) is one of cytokines, produced by macrophage, take part in differentiation T-helper (Th) to Th1 and interferon γ producing. T-helper1 play role in cellular immunity especially in viral infection include dengue. A descriptive correlative study has done to know the correlation between IL-18 levels and disease severity in admitted dengue fever (DF) and dengue hemorrhagic fever (DHF) patients. In 42 subjects consist of 20 (47.6%) DF and 22 (53.3%) DHF (grade I to IV WHO criteria, 1999) showed that IL-18 levels significantly higher in DHF than DF patients. There are significant correlation between IL-18 levels and hematocrit and low platelet value. This study supports the possible role of IL-18 in pathogenesis DHF in adults.",

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AU - Bur, Rika

AU - Matondang, Asnath

AU - Djauzi, Samsuridjal

AU - Inada, Katsuya

AU - Endo, Shigeatsu

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AB - Interleukin (IL)-18 (interferon-γ inducing factor) is one of cytokines, produced by macrophage, take part in differentiation T-helper (Th) to Th1 and interferon γ producing. T-helper1 play role in cellular immunity especially in viral infection include dengue. A descriptive correlative study has done to know the correlation between IL-18 levels and disease severity in admitted dengue fever (DF) and dengue hemorrhagic fever (DHF) patients. In 42 subjects consist of 20 (47.6%) DF and 22 (53.3%) DHF (grade I to IV WHO criteria, 1999) showed that IL-18 levels significantly higher in DHF than DF patients. There are significant correlation between IL-18 levels and hematocrit and low platelet value. This study supports the possible role of IL-18 in pathogenesis DHF in adults.

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KW - Dengue

KW - Dengue hemorrhagic fever

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KW - Pathogenesis

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Interleukin-18 levels in adult dengue fever and dengue hemorrhagic fever

Abstract

Keywords

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