Intercellular adhesive molecule-1 (Icam-1) in proliferative diabetic retinopathy

Andi A. Victor, Tjahjono D. Gondhowiardjo, Rahayuningsih Dharma, Sri W.A. Jusman, Vivi R. Yandri, Ressa Yuneta, Rizky E.P. Yuriza

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the level of intercellular adhesion molecule-1 (ICAM-1) in vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and its affecting factors including HbA1c level, duration of diabetes mellitus (DM) and insulin usage. Methods: A cross-sectional study was conducted in Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia from June 2015 to August 2016. Thirty-three consecutive vitreous samples harvested from PDR patients underwent vitrectomy. The level of vitreous ICAM-1 was determined by enzyme-linked immunosorbent assay. Results: Based on the glycemic status, vitreous ICAM-1 level in the uncontrolled glycemic group (21.61 ng/ml) was lower than controlled glycemic group (24.20 ng/ml). Patients with DM for more than 10 years had higher level of vitreous ICAM-1 (26.30 ng/ml). Vitreous ICAM-1 level in DM patients with insulin was higher than those without insulin (27.07 ng/ml vs. 24.17 ng/ml). There was no statistically significant difference between vitreous ICAM-1 levels among all groups (p > 0.05). Conclusion: The concentration of vitreous ICAM-1 may not be influenced by glucose control and conventional insulin therapy.

Original languageEnglish
Pages (from-to)120-127
Number of pages8
JournalAsian Journal of Ophthalmology
Volume17
Issue number1
Publication statusPublished - 1 Jan 2020

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Diabetic Retinopathy
Intercellular Adhesion Molecule-1
Adhesives
Insulin
Diabetes Mellitus
Indonesia
Vitrectomy
General Hospitals
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Glucose

Keywords

  • Diabetic retinopathy
  • Insulin
  • Intercellular adhesion molecule-1
  • Type 2 diabetes mellitus

Cite this

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title = "Intercellular adhesive molecule-1 (Icam-1) in proliferative diabetic retinopathy",
abstract = "Purpose: To determine the level of intercellular adhesion molecule-1 (ICAM-1) in vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and its affecting factors including HbA1c level, duration of diabetes mellitus (DM) and insulin usage. Methods: A cross-sectional study was conducted in Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia from June 2015 to August 2016. Thirty-three consecutive vitreous samples harvested from PDR patients underwent vitrectomy. The level of vitreous ICAM-1 was determined by enzyme-linked immunosorbent assay. Results: Based on the glycemic status, vitreous ICAM-1 level in the uncontrolled glycemic group (21.61 ng/ml) was lower than controlled glycemic group (24.20 ng/ml). Patients with DM for more than 10 years had higher level of vitreous ICAM-1 (26.30 ng/ml). Vitreous ICAM-1 level in DM patients with insulin was higher than those without insulin (27.07 ng/ml vs. 24.17 ng/ml). There was no statistically significant difference between vitreous ICAM-1 levels among all groups (p > 0.05). Conclusion: The concentration of vitreous ICAM-1 may not be influenced by glucose control and conventional insulin therapy.",
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author = "Victor, {Andi A.} and Gondhowiardjo, {Tjahjono D.} and Rahayuningsih Dharma and Jusman, {Sri W.A.} and Yandri, {Vivi R.} and Ressa Yuneta and Yuriza, {Rizky E.P.}",
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Intercellular adhesive molecule-1 (Icam-1) in proliferative diabetic retinopathy. / Victor, Andi A.; Gondhowiardjo, Tjahjono D.; Dharma, Rahayuningsih; Jusman, Sri W.A.; Yandri, Vivi R.; Yuneta, Ressa; Yuriza, Rizky E.P.

In: Asian Journal of Ophthalmology, Vol. 17, No. 1, 01.01.2020, p. 120-127.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Intercellular adhesive molecule-1 (Icam-1) in proliferative diabetic retinopathy

AU - Victor, Andi A.

AU - Gondhowiardjo, Tjahjono D.

AU - Dharma, Rahayuningsih

AU - Jusman, Sri W.A.

AU - Yandri, Vivi R.

AU - Yuneta, Ressa

AU - Yuriza, Rizky E.P.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Purpose: To determine the level of intercellular adhesion molecule-1 (ICAM-1) in vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and its affecting factors including HbA1c level, duration of diabetes mellitus (DM) and insulin usage. Methods: A cross-sectional study was conducted in Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia from June 2015 to August 2016. Thirty-three consecutive vitreous samples harvested from PDR patients underwent vitrectomy. The level of vitreous ICAM-1 was determined by enzyme-linked immunosorbent assay. Results: Based on the glycemic status, vitreous ICAM-1 level in the uncontrolled glycemic group (21.61 ng/ml) was lower than controlled glycemic group (24.20 ng/ml). Patients with DM for more than 10 years had higher level of vitreous ICAM-1 (26.30 ng/ml). Vitreous ICAM-1 level in DM patients with insulin was higher than those without insulin (27.07 ng/ml vs. 24.17 ng/ml). There was no statistically significant difference between vitreous ICAM-1 levels among all groups (p > 0.05). Conclusion: The concentration of vitreous ICAM-1 may not be influenced by glucose control and conventional insulin therapy.

AB - Purpose: To determine the level of intercellular adhesion molecule-1 (ICAM-1) in vitreous fluid of patients with proliferative diabetic retinopathy (PDR) and its affecting factors including HbA1c level, duration of diabetes mellitus (DM) and insulin usage. Methods: A cross-sectional study was conducted in Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia from June 2015 to August 2016. Thirty-three consecutive vitreous samples harvested from PDR patients underwent vitrectomy. The level of vitreous ICAM-1 was determined by enzyme-linked immunosorbent assay. Results: Based on the glycemic status, vitreous ICAM-1 level in the uncontrolled glycemic group (21.61 ng/ml) was lower than controlled glycemic group (24.20 ng/ml). Patients with DM for more than 10 years had higher level of vitreous ICAM-1 (26.30 ng/ml). Vitreous ICAM-1 level in DM patients with insulin was higher than those without insulin (27.07 ng/ml vs. 24.17 ng/ml). There was no statistically significant difference between vitreous ICAM-1 levels among all groups (p > 0.05). Conclusion: The concentration of vitreous ICAM-1 may not be influenced by glucose control and conventional insulin therapy.

KW - Diabetic retinopathy

KW - Insulin

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KW - Type 2 diabetes mellitus

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