Interaction Study Between Alpha-mangostin, Beta-mangostin, and Gammamangostin with Cyclooxygenase Compared to Acetosal and SC-558 as Oral Antiinflammation Drugs

Cyclooxygenase (COX) plays role in the biosynthesis of prostaglandin, a mediator of inflammation. Cyclooxygenase presents in two isoforms, COX-1 and COX-2. The objective of this study is to analyze the interaction between alpha-mangostin, beta-mangostin and gamma-mangostin with COX-1 and COX-2. The analysis method was comparing the interactions of ligands in the ligand binding domain of COX-1 and COX-2.Acetosal and SC-558 were used as the references. Alpha-mangostin, beta-mangostin, gamma-mangostin, acetosal, and SC-558 interact with cyclooxygenase receptor via hydrogen bonds, hydrophobic interaction,and van der waals interaction. Gamma-mangostin gives the best results based on the interaction energy. Beta-mangostin provides the best affinity based on the inhibition constant to COX-1, and has inhibition constant to COX-2 that half time weaker than acetosal. Alpha-mangostin, beta-mangostin, gamma-mangostincan be used as non selective COX-2 oral antiinflamatic drugs.