Inhibition of Candida albicans hypha formation in biofilm formation by Ruta angustifolia extract

Shafa Noer, Abinawanto, Boy M. Bachtiar, Anom Bowolaksono

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Ruta angustifolia is a medicinal plant often used in treating various diseases. Several studies have been carried out to reveal the chemical compounds in this plant, and some are effectively used as antimicrobials. Candida albicans is the most common pathogenic fungus in humans and causes many cases of infection. C. albicans can form biofilms on biotic and abiotic surfaces, either as mono or multispecies, that may increase its pathogenicity. In a state of forming biofilms, microbes are surrounded by an extracellular matrix that protects the microbial community from antimicrobial agents. In this study, we examined the effect of R. angustifolia extract on C. albicans biofilm formation. C. albicans preformed biofilms (24 h) were treated with various concentrations of R. angustifolia extract (100%, 50%, 20%) and incubated at 37°C for 24 h. The characteristics of biofilm formation were assessed with microscopic methods using a light microscope. The results indicated that the effect of R. angustifolia extract could inhibit the C. albicans hypha formation at all concentrations treated.

Original languageEnglish
Title of host publication2nd Science and Mathematics International Conference, SMIC 2020
Subtitle of host publicationTransforming Research and Education of Science and Mathematics in the Digital Age
EditorsMeiliasari Meiliasari, Yuli Rahmawati, Mutia Delina, Ella Fitriani
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440753
DOIs
Publication statusPublished - 2 Apr 2021
Event2nd Science and Mathematics International Conference: Transforming Research and Education of Science and Mathematics in the Digital Age, SMIC 2020 - Jakarta, Indonesia
Duration: 8 Aug 20209 Aug 2020

Publication series

NameAIP Conference Proceedings
Volume2331
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference2nd Science and Mathematics International Conference: Transforming Research and Education of Science and Mathematics in the Digital Age, SMIC 2020
Country/TerritoryIndonesia
CityJakarta
Period8/08/209/08/20

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