Influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients.

Agus W. Nugroho; Evy Yunihastuti; Meta S.S. Wiria

Influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients.

Nafrialdi, Agus W. Nugroho, Evy Yunihastuti, Meta S.S. Wiria

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

to evaluate the influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients. this was a cross sectional study on 40 HIV patients (16 with HIV-TB coinfection, and 24 HIV without TB) conducted in HIV-AIDS study group (Pokdisus AIDS) of Cipto Mangunkusumo Hospital, Jakarta in October-November 2008. Those who had consumed both drugs for at least 2 weeks were recruited. Plasma nevirapine level was measured by using HPLC method, and the comparison between the two groups was done by unpaired t-test. Nevirapine plasma level (mean±SD) in HIV patient was 7.5±2.2 ug/ml, while in HIV-TB patients it was 5.5±2.7 ug/ml (p=0.018). In most of patients receiving rifampicin, the plasma nevirapine concentration was still in therapeutic range. co-administration of rifampicin was associated with a significant decrease in nevirapin plasma concentration. However, this level was still in therapeutic range.

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Acta medica Indonesiana
Volume	44
Issue number	2
Publication status	Published - Apr 2012

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title = "Influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients.",

abstract = "to evaluate the influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients. this was a cross sectional study on 40 HIV patients (16 with HIV-TB coinfection, and 24 HIV without TB) conducted in HIV-AIDS study group (Pokdisus AIDS) of Cipto Mangunkusumo Hospital, Jakarta in October-November 2008. Those who had consumed both drugs for at least 2 weeks were recruited. Plasma nevirapine level was measured by using HPLC method, and the comparison between the two groups was done by unpaired t-test. Nevirapine plasma level (mean±SD) in HIV patient was 7.5±2.2 ug/ml, while in HIV-TB patients it was 5.5±2.7 ug/ml (p=0.018). In most of patients receiving rifampicin, the plasma nevirapine concentration was still in therapeutic range. co-administration of rifampicin was associated with a significant decrease in nevirapin plasma concentration. However, this level was still in therapeutic range.",

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AU - Wiria, Meta S.S.

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AB - to evaluate the influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients. this was a cross sectional study on 40 HIV patients (16 with HIV-TB coinfection, and 24 HIV without TB) conducted in HIV-AIDS study group (Pokdisus AIDS) of Cipto Mangunkusumo Hospital, Jakarta in October-November 2008. Those who had consumed both drugs for at least 2 weeks were recruited. Plasma nevirapine level was measured by using HPLC method, and the comparison between the two groups was done by unpaired t-test. Nevirapine plasma level (mean±SD) in HIV patient was 7.5±2.2 ug/ml, while in HIV-TB patients it was 5.5±2.7 ug/ml (p=0.018). In most of patients receiving rifampicin, the plasma nevirapine concentration was still in therapeutic range. co-administration of rifampicin was associated with a significant decrease in nevirapin plasma concentration. However, this level was still in therapeutic range.

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Influence of rifampicin on nevirapine plasma concentration in HIV-TB coinfected patients.

Abstract

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