Abstract
Background: Coronavirus disease 2019 (COVID-19) may cause dysregulation of the immune system, leading to hyperinflammation. Inflammatory markers can be used to predict in-hospital mortality in COVID-19 patients. This research was aimed to investigate the association between the levels of various inflammatory markers and mortality in COVID-19 patients.
Methods: This study was conducted at Persahabatan National Respiratory Referral Hospital, Indonesia. Blood tests were performed upon admission, measuring the C-reactive protein, PCT, leukocyte, differential counts, and platelet count. The outcome measured was the mortality of hospitalized COVID-19 patients. Statistical analysis methods included the Mann–Whitney U test, receiver operating characteristic (ROC) analysis, and area under the curve (AUC) test.
Results: Total 110 patients were included, and the laboratory values were analyzed to compare survivors and non-survivors. The non-survivor
group had significantly higher leukocyte count, lower lymphocyte count, higher CRP and PCT levels, higher neutrophil -to-lymphocyte ratio (NLR), higher platelet-to-lymphocyte ratio (PLR), and lower lymphocyte-to-CRP ratio. As predictors of mortality, AUC analysis revealed that PCT, CRP, NLR, and PLR had AUCs of 0.867, 0.82, 0.791, and 0.746, respectively.
Conclusions: Routine and affordable inflammatory markers tested on admission may be useful as predictors of in-hospital mortality in COVID-
19 patients requiring hospitalization. (J Respirol Indones 2021; 41(4): 252–9)
Methods: This study was conducted at Persahabatan National Respiratory Referral Hospital, Indonesia. Blood tests were performed upon admission, measuring the C-reactive protein, PCT, leukocyte, differential counts, and platelet count. The outcome measured was the mortality of hospitalized COVID-19 patients. Statistical analysis methods included the Mann–Whitney U test, receiver operating characteristic (ROC) analysis, and area under the curve (AUC) test.
Results: Total 110 patients were included, and the laboratory values were analyzed to compare survivors and non-survivors. The non-survivor
group had significantly higher leukocyte count, lower lymphocyte count, higher CRP and PCT levels, higher neutrophil -to-lymphocyte ratio (NLR), higher platelet-to-lymphocyte ratio (PLR), and lower lymphocyte-to-CRP ratio. As predictors of mortality, AUC analysis revealed that PCT, CRP, NLR, and PLR had AUCs of 0.867, 0.82, 0.791, and 0.746, respectively.
Conclusions: Routine and affordable inflammatory markers tested on admission may be useful as predictors of in-hospital mortality in COVID-
19 patients requiring hospitalization. (J Respirol Indones 2021; 41(4): 252–9)
| Original language | English |
|---|---|
| Pages (from-to) | 252-259 |
| Journal | Jurnal Respirologi Indonesia |
| Volume | 41 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 27 Nov 2021 |
Keywords
- biomarkers; COVID-19; mortality; prognosis