Inflammatory cytokine serum levels in sockets following extraction of teeth with apical periodontitis

Meiny F. Amin, Ratna Meidyawati, Melanie S. Djamil, Benny S. Latief

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5 Citations (Scopus)


Porphyromonas endodontalis triggers macrophages and T-lymphocytes to release inflammatory cytokines serum level, including interleukin-1β (IL-1β), IL-6, IL-17), and tumor necrosis factor-α (TNF-α). P. endodontalis is one of the bacteria that causes apical periodontitis (AP). To investigate of various inflammatory cytokines serum levels (IL-1β, IL-6, IL-17, TNF-α) in socket blood following tooth extraction due to AP. We performed an observational analytical study on 10 teeth with AP compared with 10 normal teeth without periodontitis. The teeth were extracted and blood was extracted from the socket using foam, squeezed in a 2 mL Eppendorf tube, and centrifuged to separate the serum. Enzyme-linked immunosorbent assay (ELISA) was used to measure all the inflammatory cytokine serum levels. On t-test, IL-1β levels in the socket blood following extraction of teeth with AP (4344.00 ± 2196.00 pg/mL) were significantly higher (t = 6.71; p < 0.05) compared to the controls (520.80 ± 213.70 pg/mL); IL-6 levels in AP (88.99 ± 35.66 pg/mL) were significantly higher (t = 8.99; p < 0.05) compared to the controls (13.70 ± 7.07 pg/mL); IL-17 levels in AP (68.50 ± 38.90 pg/mL) were significantly higher (t = 5.07; p < 0.05) compared to the controls (8.19 ± 3.82 pg/mL); and TNF-α levels in AP (1816.00 ± 966.30 pg/mL) were significantly higher compared to the controls (307.10 ± 154.60 pg/mL) (t = 6.19; p < 0.05). The level of inflammatory cytokines serum in the socket following tooth extraction increases in teeth with AP.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalJournal of International Dental and Medical Research
Issue number1
Publication statusPublished - 1 Jan 2019


  • Apical periodontitis
  • Inflammatory cytokines serum
  • Post tooth extraction
  • Socket blood


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